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USP11 and PML
Data Source:
BioGRID
(enzymatic study)
USP11
PML
Description
ubiquitin specific peptidase 11
PML nuclear body scaffold
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Cytosol
Chromosome, Telomeric Region
Chromatin
Heterochromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nuclear Matrix
PML Body
Early Endosome Membrane
Extrinsic Component Of Endoplasmic Reticulum Membrane
Molecular Function
RNA Polymerase II Transcription Corepressor Binding
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
SUMO Binding
Protein Homodimerization Activity
SMAD Binding
Sumo-dependent Protein Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Viral Process
Protein Deubiquitination
Protein Phosphopantetheinylation
Response To Hypoxia
Regulation Of Protein Phosphorylation
Regulation Of Transcription, DNA-templated
Protein Import Into Nucleus
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Cycle Arrest
Transforming Growth Factor Beta Receptor Signaling Pathway
Common-partner SMAD Protein Phosphorylation
Negative Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Response To UV
Response To Gamma Radiation
Regulation Of Calcium Ion Transport Into Cytosol
Fibroblast Migration
Viral Process
Negative Regulation Of Angiogenesis
Protein Ubiquitination
Myeloid Cell Differentiation
Regulation Of Cell Adhesion
Negative Regulation Of Cell Growth
PML Body Organization
Positive Regulation Of Telomere Maintenance
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Interleukin-1 Beta Production
Circadian Regulation Of Gene Expression
Response To Cytokine
Regulation Of Circadian Rhythm
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Entrainment Of Circadian Clock By Photoperiod
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
Cell Fate Commitment
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Fibroblast Proliferation
Retinoic Acid Receptor Signaling Pathway
Maintenance Of Protein Location In Nucleus
Defense Response To Virus
Interferon-gamma-mediated Signaling Pathway
Branching Involved In Mammary Gland Duct Morphogenesis
Protein-containing Complex Assembly
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Cellular Response To Interleukin-4
Cellular Senescence
Extrinsic Apoptotic Signaling Pathway
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Viral Release From Host Cell
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Double-strand Break Repair
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Association of TriC/CCT with target proteins during biosynthesis
Ub-specific processing proteases
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Regulation of TP53 Activity through Acetylation
Interferon gamma signaling
Regulation of RUNX1 Expression and Activity
Regulation of PTEN localization
HCMV Early Events
Drugs
Arsenic trioxide
Diseases
Acute myeloid leukemia (AML)
GWAS
Accelerometer-based physical activity measurement (fraction of time with accelerations >425 milli-gravities) (
29899525
)
Appendicular lean mass (
33097823
)
Birth weight (
31043758
)
Height (
28552196
20881960
25282103
)
Insomnia symptoms (never/rarely vs. sometimes/usually) (
30804566
)
Insomnia symptoms (never/rarely vs. usually) (
30804566
)
Myopia (pathological) (
23049088
)
Paget's disease (
21623375
)
Physical activity (overall physical activity time) (
30531941
)
White blood cell count (
32888494
)
Interacting Genes
21 interacting genes:
BMI1
BRCA2
CBX8
CDKN1A
DECR2
EIF4B
LIMS1
LLGL1
MBD3
MTA2
PCGF2
PML
RANBP9
RELB
RNF2
RPS6KB1
SETDB1
SUMO2
TBL3
TP53
UBC
109 interacting genes:
ADH1B
ANKRD2
ARID3A
ARNT
ATF2
ATXN1
AURKA
AXIN1
BANP
BCL2
BCL6
CASP8AP2
CCNT1
CDK1
CDK2
CDK6
CHFR
CREBBP
CSNK2A1
DAXX
EGFR
EIF4E
ELF4
EP300
ERCC6
FOS
GATA1
GATA2
HDAC1
HDAC2
HDAC3
HHEX
HIPK2
HTT
KAT5
KAT6A
KLHL20
MAD1L1
MAPK11
MAPK14
MDM2
MED7
MXD1
MYB
MYC
NACC1
NCOA2
NCOR1
NCOR2
NFKB1
NR3C1
NR4A1
PAWR
PAXIP1
PCBD2
PIAS1
PIAS2
PIN1
PLAGL1
PLSCR1
POLR2E
PPARG
PSMA3
RARA
RB1
RBX1
RELA
RNF111
RNF125
RPL11
RXRA
SENP1
SENP2
SH3GL1
SIAH2
SIN3A
SIRT1
SKI
SMAD3
SP1
SP100
SRF
STAT3
SUMO1
SUMO2
SUMO3
SUV39H1
SYNE2
TDG
TERF2IP
TGFBR1
TGFBR2
TGIF1
THRA
TOPBP1
TP53
TP63
TP73
TRIB3
TRIM24
TRIM27
TRIM69
UBE2I
UBE2U
UBE3A
USP11
ZBTB16
ZFYVE9
ZNF451
Entrez ID
8237
5371
HPRD ID
02081
00023
Ensembl ID
ENSG00000102226
ENSG00000140464
Uniprot IDs
B4DGK3
P51784
P29590
PDB IDs
4MEL
5OK6
1BOR
2MVW
2MWX
4WJN
4WJO
5YUF
6IMQ
6UYO
6UYP
6UYQ
6UYR
6UYS
6UYT
6UYU
6UYV
Enriched GO Terms of Interacting Partners
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