NLRX1 and PDZD3

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		NLRX1	PDZD3
Description		NLR family member X1	PDZ domain containing 3
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Plasma Membrane Cell Junction	Cytosol Brush Border Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell
	Molecular Function	Protein Binding ATP Binding	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding
	Biological Process	Viral Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity Protein Localization To Plasma Membrane
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling	Intestinal infectious diseases
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494)
Interacting Genes		1 interacting genes: SARM1	18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8
Entrez ID		79671	79849
HPRD ID		17640	06191
Ensembl ID		ENSG00000160703	ENSG00000172367
Uniprot IDs		Q86UT6	B0YJ61 Q86UT5
PDB IDs		3UN9	2V90
Enriched GO Terms of Interacting Partners?
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