SEMA3B and PAK6

Data Source:
BioGRID (two hybrid)

		SEMA3B	PAK6
Description		semaphorin 3B	p21 (RAC1) activated kinase 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Integral Component Of Plasma Membrane Collagen-containing Extracellular Matrix	Fibrillar Center Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	Semaphorin Receptor Binding Chemorepellent Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Neural Crest Cell Migration Cell-cell Signaling Axon Guidance Positive Regulation Of Cell Migration Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Chemorepulsion Of Axon Semaphorin-plexin Signaling Pathway	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Neuron Projection Arborization Neuron Projection Extension
Pathways			Activation of RAC1
Drugs			Fostamatinib
Diseases
GWAS		Obese vs. thin ( 30677029) Sleep duration (short sleep) ( 30846698)	Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)
Interacting Genes		22 interacting genes: BOLL CARD10 CYSRT1 HSF2BP KPRP KRTAP1-1 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP19-5 KRTAP5-9 MDFI NAA10 NBPF19 NOTCH2NLA NRP1 NRP2 PAK6 PICK1 RBPMS2 SEMA3A TRIP13	20 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 HSF2BP LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ RHOV SEMA3B SNX2 TPD52L1
Entrez ID		7869	56924
HPRD ID		03179	06426
Ensembl ID		ENSG00000012171	ENSG00000137843
Uniprot IDs		A0A0C4DGV8 B4DEK9 Q13214 Q6PI51	A0A024R9Q4 Q9NQU5
PDB IDs			2C30 2ODB 4KS7 4KS8 6QDR 6QDS
Enriched GO Terms of Interacting Partners?
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