GET1 and SCN3A

Data Source:
HPRD (two hybrid)

		GET1	SCN3A
Description		guided entry of tail-anchored proteins factor 1	sodium voltage-gated channel alpha subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Voltage-gated Sodium Channel Complex Cytoplasm Axon
	Molecular Function	Protein Binding	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity
	Biological Process	Tail-anchored Membrane Protein Insertion Into ER Membrane	Sodium Ion Transport Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Membrane Depolarization During Action Potential
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Zonisamide Promethazine Tetrodotoxin Brivaracetam Lacosamide Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases
GWAS			Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Epilepsy ( 30531953) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953) Metabolite levels ( 23823483) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Parkinson's disease ( 28892059) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		28 interacting genes: ABHD5 APOA2 APOL2 AQP1 CAMLG CCL4L2 CD302 CD53 CLCN7 COMT COX20 ERG28 HMOX2 HTATIP2 ORMDL3 PLPP4 PTPN9 RASGRP3 RTP2 SERP2 SLC35E3 SLC7A1 SPTSSA STX2 TECR TFRC TM4SF19 TMEM42	5 interacting genes: CNTN1 LRP1 LRP2 LRP8 PRKCG
Entrez ID		7485	6328
HPRD ID		04224	01671
Ensembl ID		ENSG00000182093	ENSG00000153253
Uniprot IDs		O00258	A0A590UJH3 Q9C007 Q9NY46
PDB IDs		6SO5
Enriched GO Terms of Interacting Partners?
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