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NR1H2 and ERG28
Data Source:
BioGRID
(two hybrid)
NR1H2
ERG28
Description
nuclear receptor subfamily 1 group H member 2
ergosterol biosynthesis 28 homolog
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Transport Vesicle
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Apolipoprotein A-I Receptor Binding
Retinoid X Receptor Binding
ATPase Binding
Molecular_function
Protein Binding
Protein-macromolecule Adaptor Activity
Identical Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Triglyceride Biosynthetic Process
Positive Regulation Of Cholesterol Efflux
Positive Regulation Of Lipid Storage
Negative Regulation Of Cholesterol Storage
Cell Differentiation
Response To Nutrient Levels
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Lipid Transport
Positive Regulation Of Cholesterol Transport
Phosphatidylcholine Acyl-chain Remodeling
Cholesterol Homeostasis
Positive Regulation Of Fatty Acid Biosynthetic Process
Negative Regulation Of Proteolysis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Retinoic Acid Receptor Signaling Pathway
Negative Regulation Of Pinocytosis
Positive Regulation Of Lipoprotein Lipase Activity
Negative Regulation Of Interferon-gamma-mediated Signaling Pathway
Positive Regulation Of High-density Lipoprotein Particle Assembly
Positive Regulation Of Pancreatic Juice Secretion
Positive Regulation Of Secretion Of Lysosomal Enzymes
Negative Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Response To Endoplasmic Reticulum Stress
Biological_process
Sterol Biosynthetic Process
Pathways
PPARA activates gene expression
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
VLDLR internalisation and degradation
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs
GW-3965
Benzenesulfinic acid
TO-901317
1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL
Diacerein
Rhein
Diseases
GWAS
Interacting Genes
51 interacting genes:
BAG6
CDKN1A
CHD3
COL4A5
CSAD
DNMT3L
DUSP12
ERG28
FAF1
FOXO3
HDAC4
HMGXB4
ING3
KDM1A
LAMC3
MDFI
MED1
MPP1
NCOA1
NCOA3
NCOA6
NCOR1
NCOR2
NPY
NR0B2
NRIP1
PCDH17
PPARA
PPARD
PPARG
PRKCA
RARA
RHOU
RMI1
ROBO2
RXRA
RXRB
RXRG
SCG5
SIRT1
SMPD1
SORBS2
SPRY2
SUV39H1
TMEM161A
UBE2D1
UBE2I
VDR
VIM
YY1
ZXDC
124 interacting genes:
ALDH2
ANXA1
ANXA7
AQP2
AQP3
AQP6
BAIAP2
BCL2L13
BID
BTBD2
CCDC106
CCL18
CD53
CD74
CDC42
CDK5RAP2
CELF3
CLDN5
CLDN7
CLN8
COX17
CRADD
CREB1
CREB3
CREB3L1
CSTF2
CYB561
DYNLL1
EBP
ELOVL4
ERBB2
ERBB3
ERBB4
FAM174A
FAM209A
FAS
FCGR2B
FFAR2
FXR1
FXYD3
GADD45A
GET1
GJB5
GPR152
GPR37L1
GPX8
GSK3B
HMGB1
HNRNPH3
HNRNPUL1
HSD17B11
HSPE1
HTR2C
HYLS1
JAGN1
KCNJ6
KLHL20
LHFPL5
LMNA
LSM2
LYPD5
MAPK8IP2
MFSD14B
MGST3
MPHOSPH6
MRM1
MRPL38
MRPS12
MS4A3
MSMO1
MTERF3
MTNR1B
MUC1
NAT9
NCR3LG1
NDUFA3
NDUFA4L2
NR1H2
NSF
PAFAH1B3
PCDHA4
PDZK1IP1
PEX2
PFN1
PHYHIP
PIGY
POLE2
POLR2C
POLR3F
PPP1R8
PQBP1
PSCA
RAB27A
REEP4
RETREG3
RPS6KA6
S100A8
SAR1A
SAT1
SCN3B
SEPHS1
SERPINB9
SGPL1
SLC10A6
SLC26A6
SLC34A2
SNRPB
SNRPG
SSMEM1
STOM
STX1A
SULT1E1
TFG
TK1
TLCD4
TM4SF19
TMEM106A
TMEM222
TMEM31
TMPRSS2
TSC22D1
TTR
ZFP64
ZNF24
Entrez ID
7376
11161
HPRD ID
02660
05201
Ensembl ID
ENSG00000131408
ENSG00000133935
Uniprot IDs
F1D8P7
P55055
Q6FII3
Q86TW5
Q9UKR5
PDB IDs
1P8D
1PQ6
1PQ9
1PQC
1UPV
1UPW
3KFC
3L0E
4DK7
4DK8
4NQA
4RAK
5HJP
5I4V
5JY3
5KYA
5KYJ
6JIO
6K9G
6K9H
6K9M
6S4N
6S4T
6S4U
6S5K
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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