TYMS and NDUFV2

Data Source:
BioGRID (affinity chromatography technology)

		TYMS	NDUFV2
Description		thymidylate synthetase	NADH:ubiquinone oxidoreductase core subunit V2
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Cytosol
	Molecular Function	Translation Repressor Activity, MRNA Regulatory Element Binding Thymidylate Synthase Activity Folic Acid Binding Drug Binding Protein Homodimerization Activity Sequence-specific MRNA Binding	Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DTMP Biosynthetic Process DTTP Biosynthetic Process Aging Circadian Rhythm Response To Toxic Substance Nucleobase-containing Small Molecule Interconversion Negative Regulation Of Translation Modulation By Virus Of Host Process Uracil Metabolic Process Methylation Response To Progesterone Response To Vitamin A Response To Cytokine Tetrahydrofolate Interconversion Response To Drug Response To Ethanol Response To Organophosphorus Developmental Growth Cartilage Development Response To Glucocorticoid Response To Folic Acid Intestinal Epithelial Cell Maturation DNA Biosynthetic Process Liver Regeneration	Mitochondrial Electron Transport, NADH To Ubiquinone Nervous System Development Mitochondrial Respiratory Chain Complex I Assembly Cardiac Muscle Tissue Development
Pathways		Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription	Respiratory electron transport Complex I biogenesis
Drugs		Raltitrexed Floxuridine Trifluridine Gemcitabine Fluorouracil Methotrexate Pemetrexed Capecitabine Thymidine monophosphate 10-Propargyl-5,8-Dideazafolic Acid Deoxyuridine monophosphate S,S-(2-Hydroxyethyl)Thiocysteine Thymectacin ANX-510 OSI-7904L Pralatrexate 2,4-Diamino-5-phenyl-6-ethylpyrimidine N-[2-Chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide 6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE Tegafur Tegafur-uracil	NADH
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Leukocyte telomere length ( 32109421 31171785) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Testicular germ cell tumor ( 28604728) Urinary metabolite levels in chronic kidney disease ( 31959995)	Cerebral amyloid deposition (PET imaging) ( 26252872) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Platelet distribution width ( 32888494) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		3 interacting genes: CDC42 SH3GL2 UPF2	6 interacting genes: CCNC CRMP1 FAM114A2 GOLM1 KAT5 SP110
Entrez ID		7298	4729
HPRD ID		01774	02757
Ensembl ID		ENSG00000176890	ENSG00000178127
Uniprot IDs		P04818 Q53Y97	P19404
PDB IDs		1HVY 1HW3 1HW4 1HZW 1I00 1JU6 1JUJ 1YPV 2ONB 2RD8 2RDA 3EAW 3EBU 3ED7 3EDW 3EF9 3EGY 3EHI 3EJL 3GG5 3GH0 3GH2 3H9K 3HB8 3N5E 3N5G 3OB7 4E28 4FGT 4G2O 4G6W 4GD7 4GYH 4H1I 4JEF 4KPW 4O1U 4O1X 4UP1 5HS3 5WRN 5X4W 5X4X 5X4Y 5X5A 5X5D 5X5Q 5X66 5X67 5X69 6OJU 6OJV 6PF3 6PF4 6PF5 6PF6 6QXG 6QXH 6QYQ 6R2E	5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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