TRH and CD80

Data Source:
BioGRID (enzymatic study)

		TRH	CD80
Description		thyrotropin releasing hormone	CD80 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Plasma Membrane Secretory Granule	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Protein Complex Involved In Cell Adhesion
	Molecular Function	Protein Binding Thyrotropin-releasing Hormone Activity	Virus Receptor Activity Protein Binding Coreceptor Activity
	Biological Process	Response To Hypoxia Histamine Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Cold Response To Glucose Hormone-mediated Signaling Pathway Negative Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Insulin Secretion Eating Behavior Response To Ethanol Response To Corticosterone Negative Regulation Of Feeding Behavior	Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway T Cell Costimulation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-2 Production Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Abatacept Galiximab Belatacept
Diseases
GWAS		Alzheimer's disease ( 30636644) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Asthma ( 32296059) Autoimmune thyroid disease ( 32581359) Carotid plaque burden ( 28282560) Celiac disease ( 20190752) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lobular breast cancer (menopausal hormone therapy interaction) ( 24080446) Primary biliary cholangitis ( 28425483 23000144 21399635 26394269 28062665) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 23273568 25862617) Systemic sclerosis ( 31672989) Vitiligo ( 27723757 22561518)
Interacting Genes		5 interacting genes: ARRB2 CPE KCNIP4 LCN2 TRHR	5 interacting genes: CD274 CD28 CD86 CTLA4 NGFR
Entrez ID		7200	941
HPRD ID		08944	00202
Ensembl ID		ENSG00000170893	ENSG00000121594
Uniprot IDs		P20396	A0N0P2 P33681
PDB IDs			1DR9 1I8L
Enriched GO Terms of Interacting Partners?
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