TNP1 and ICOS

Data Source:
BioGRID (affinity chromatography technology)

		TNP1	ICOS
Description		transition protein 1	inducible T cell costimulator
Image		No pdb structure
GO Annotations	Cellular Component	Nucleosome Male Germ Cell Nucleus Nucleus	Extracellular Region Plasma Membrane Integral Component Of Membrane
	Molecular Function	DNA Binding Protein Binding	Protein Binding
	Biological Process	Single Strand Break Repair Nucleosome Disassembly Chromatin Remodeling Chromatin Silencing Multicellular Organism Development Spermatid Development Spermatid Nucleus Differentiation Spermatid Nucleus Elongation Positive Regulation Of Protein Processing Sexual Reproduction Flagellated Sperm Motility Fertilization, Exchange Of Chromosomal Proteins Spermatogenesis, Exchange Of Chromosomal Proteins Negative Regulation Of Transcription, DNA-templated	T Cell Tolerance Induction Immune Response T Cell Costimulation Positive Regulation Of Protein Kinase B Signaling Cell-cell Adhesion
Pathways
Drugs
Diseases			Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate ( 29403010) Height ( 25282103 31562340) Hypothyroidism ( 27182965) Mitral valve prolapse ( 26301497) Permanent tooth development ( 21931568) Pulse pressure ( 27841878) Thyroid stimulating hormone levels ( 32769997)	Alopecia areata ( 20596022 25608926) Aluminium levels ( 26025379) Body mass index ( 28892062) Celiac disease ( 20190752) Diastolic blood pressure ( 30224653) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Ulcerative colitis ( 26192919)
Interacting Genes		10 interacting genes: CSNK2A1 DVL3 PPARA PPARD PPARG PRKACA PRKACB PRKACG PRKCA SDCBP2	4 interacting genes: ICOSLG NUFIP2 RC3H1 WIF1
Entrez ID		7141	29851
HPRD ID		01830	09196
Ensembl ID		ENSG00000118245	ENSG00000163600
Uniprot IDs		P09430 Q4ZG82	Q53QY6 Q9Y6W8
PDB IDs			6X4G 7JOO
Enriched GO Terms of Interacting Partners?
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