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NKX2-1 and WWTR1
Data Source:
HPRD
(in vivo, in vitro)
NKX2-1
WWTR1
Description
NK2 homeobox 1
WW domain containing transcription regulator 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Plasma Membrane
Nuclear Body
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Intronic Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Protein Homodimerization Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Neuron Migration
Regulation Of Transcription By RNA Polymerase II
Phospholipid Metabolic Process
Axon Guidance
Brain Development
Endoderm Development
Locomotory Behavior
Response To Hormone
Positive Regulation Of Gene Expression
Negative Regulation Of Epithelial To Mesenchymal Transition
Globus Pallidus Development
Hippocampus Development
Cerebral Cortex Cell Migration
Forebrain Dorsal/ventral Pattern Formation
Forebrain Neuron Fate Commitment
Cerebral Cortex GABAergic Interneuron Differentiation
Pituitary Gland Development
Cell Differentiation
Lung Development
Negative Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Thyroid Gland Development
Forebrain Development
Developmental Induction
Leydig Cell Differentiation
Positive Regulation Of Circadian Rhythm
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Anatomical Structure Formation Involved In Morphogenesis
Oligodendrocyte Differentiation
Lung Saccule Development
Epithelial Tube Branching Involved In Lung Morphogenesis
Club Cell Differentiation
Type II Pneumocyte Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Osteoblast Differentiation
Tissue Homeostasis
Negative Regulation Of Protein Phosphorylation
Heart Process
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Negative Regulation Of Protein Kinase Activity
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition
Protein Ubiquitination
Stem Cell Division
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Glomerulus Development
Multicellular Organism Growth
Hippo Signaling
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Mesenchymal Cell Differentiation
Cilium Assembly
Regulation Of SMAD Protein Signal Transduction
Kidney Morphogenesis
Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
Pathways
Signaling by Hippo
YAP1- and WWTR1 (TAZ)-stimulated gene expression
YAP1- and WWTR1 (TAZ)-stimulated gene expression
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Physiological factors
RUNX2 regulates osteoblast differentiation
RUNX3 regulates YAP1-mediated transcription
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
Choreoathetosis, hypothyroidism, and neonatal respiratory distress
GWAS
Differentiated thyroid cancer (
28703219
)
Height (
18391950
)
Menarche (age at onset) (
23667675
29773799
)
Papillary thyroid cancer (
28703219
)
Thyroid cancer (
19198613
)
Height (
31562340
)
Polycystic ovary syndrome (
32289280
)
Preeclampsia (
23551011
)
Interacting Genes
15 interacting genes:
CALR
CAVIN1
CREBBP
FOXA1
GATA6
HIPK2
MAPK1
NCOA1
NCOA2
NCOA3
PAX8
RARA
RELA
TDG
WWTR1
22 interacting genes:
C1orf74
DAPK1
IL16
LATS1
LATS2
MFHAS1
NKX2-1
PAX3
PPP1CA
RTN4IP1
RUNX1
SLC9A3R2
SUMO3
TCP11L1
TEAD1
TEAD2
TEAD3
TEAD4
WBP2
YWHAE
YWHAG
YWHAZ
Entrez ID
7080
25937
HPRD ID
02798
09580
Ensembl ID
ENSG00000136352
ENSG00000018408
Uniprot IDs
P43699
Q9GZV5
PDB IDs
5N5R
5N5T
5N5W
5N75
6RHC
6RJL
6RJQ
6RP6
6SLW
6SLX
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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