TCF7 and JADE2

Data Source:
BioGRID (affinity chromatography technology)

		TCF7	JADE2
Description		transcription factor 7	jade family PHD finger 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Beta-catenin-TCF Complex	Histone Acetyltransferase Complex Nucleoplasm Extracellular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity Protein Binding Beta-catenin Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Transferase Activity Metal Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Immune Response T Cell Receptor V(D)J Recombination Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Canonical Wnt Signaling Pathway Cellular Response To Interleukin-4 Beta-catenin-TCF Complex Assembly	Protein Ubiquitination Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes RUNX3 regulates WNT signaling	HATs acetylate histones
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Menarche (age at onset) ( 25231870) Multiple sclerosis ( 31604244 24076602 21833088) Rheumatoid arthritis ( 32868391) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338 28714469) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Adult body size ( 32376654) Age at first birth ( 27798627) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) Coffee consumption ( 31046077) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hand grip strength ( 29691431) Household income (MTAG) ( 31844048) Mental health study participation (completed survey) ( 31263887) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Platelet distribution width ( 27863252) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 28869590) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: SS18L1 UCHL5	16 interacting genes: CBX8 CDCA7L CSNK2A1 FBXO7 GAS2L2 GORASP2 H3-4 ING4 ING5 MEAF6 PACSIN1 SASH1 ZBTB3 ZBTB5 ZNF417 ZNF496
Entrez ID		6932	23338
HPRD ID		01797	15124
Ensembl ID		ENSG00000081059	ENSG00000043143
Uniprot IDs		B3KQ75 P36402	A0A0C4DFT8 B3KPL2 B4DFY8 G3XAA4 Q9NQC1
PDB IDs
Enriched GO Terms of Interacting Partners?
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