SULT1A3 and SHMT1

Data Source:
BioGRID (two hybrid)

		SULT1A3	SHMT1
Description		sulfotransferase family 1A member 3	serine hydroxymethyltransferase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Aryl Sulfotransferase Activity Protein Binding Sulfotransferase Activity Sulfate Binding Amine Sulfotransferase Activity	Translation Repressor Activity, MRNA Regulatory Element Binding Glycine Hydroxymethyltransferase Activity Protein Binding Zinc Ion Binding L-allo-threonine Aldolase Activity Pyridoxal Phosphate Binding Small Molecule Binding Identical Protein Binding Protein Homodimerization Activity MRNA 5'-UTR Binding Cobalt Ion Binding Serine Binding
	Biological Process	Ethanol Catabolic Process Xenobiotic Metabolic Process Dopamine Receptor Signaling Pathway Steroid Metabolic Process Flavonoid Metabolic Process IRE1-mediated Unfolded Protein Response Dopamine Catabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation ERK1 And ERK2 Cascade Calcineurin-mediated Signaling NMDA Selective Glutamate Receptor Signaling Pathway Negative Regulation Of Neuron Death Cellular Response To Dopamine	Glycine Metabolic Process L-serine Metabolic Process L-serine Catabolic Process One-carbon Metabolic Process Purine Nucleobase Biosynthetic Process Negative Regulation Of Translation Glycine Biosynthetic Process From Serine Tetrahydrofolate Interconversion Carnitine Biosynthetic Process Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Protein Homotetramerization Cellular Response To Tetrahydrofolate Cellular Response To Leukemia Inhibitory Factor
Pathways		Cytosolic sulfonation of small molecules XBP1(S) activates chaperone genes Cytosolic sulfonation of small molecules	Metabolism of folate and pterines Carnitine synthesis
Drugs			Pyridoxal phosphate Tetrahydrofolic acid Glycine Mimosine Triglu-5-formyl-tetrahydrofolate 5-hydroxymethyl-5,6-dihydrofolic acid N-Pyridoxyl-Glycine-5-Monophosphate
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Blood protein levels ( 30072576) Change in neurofilament light levels ( 31295725) Multiple sclerosis ( 27386562)
Interacting Genes		6 interacting genes: APP KHDRBS2 NIF3L1 SHMT1 SMN1 TK1	11 interacting genes: CSNK2B DDX6 DEDD DLEU1 FBXO7 GORASP2 MAPK9 MDFI PIM1 PRSS23 SULT1A3
Entrez ID		6818	6470
HPRD ID		07199	01643
Ensembl ID		ENSG00000261052	ENSG00000176974
Uniprot IDs		P0DMM9 P0DMN0 Q1ET61	P34896
PDB IDs		1CJM 2A3R	1BJ4 6FL5
Enriched GO Terms of Interacting Partners?
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