SRM and ASXL1

Data Source:
BioGRID (two hybrid)

		SRM	ASXL1
Description		spermidine synthase	ASXL transcriptional regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleoplasm PR-DUB Complex
	Molecular Function	Spermidine Synthase Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding
	Biological Process	Polyamine Metabolic Process Polyamine Biosynthetic Process Spermidine Biosynthetic Process Cellular Response To Leukemia Inhibitory Factor	Cell Morphogenesis Heart Morphogenesis Transcription, DNA-templated Animal Organ Morphogenesis Negative Regulation Of Lipid Storage Protein Deubiquitination Hemopoiesis Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Monoubiquitinated Histone H2A Deubiquitination Regulation Of Kidney Size Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Thymus Development Bone Marrow Development Homeostasis Of Number Of Cells Lung Saccule Development Glomerular Visceral Epithelial Cell Development
Pathways		Metabolism of polyamines	UCH proteinases
Drugs
Diseases			C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
GWAS		Beard thickness ( 26926045)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908) Red cell distribution width ( 32888494)
Interacting Genes		3 interacting genes: CDC42 SOX12 TERF1	6 interacting genes: APP GOLGA6L9 H1-2 SRPK1 STAT3 UBC
Entrez ID		6723	171023
HPRD ID		01692	16516
Ensembl ID		ENSG00000116649	ENSG00000171456
Uniprot IDs		P19623	Q498B9 Q8IXJ9
PDB IDs		2O05 2O06 2O07 2O0L 3RW9
Enriched GO Terms of Interacting Partners?
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