TTC23 and XRN2

Data Source:
BioGRID (two hybrid)

		TTC23	XRN2
Description		tetratricopeptide repeat domain 23	5'-3' exoribonuclease 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cilium	Nucleus Nucleoplasm Nucleolus Membrane Aggresome
	Molecular Function	Protein Binding	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Smoothened Signaling Pathway	DNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Autism spectrum disorder ( 30804558) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		99 interacting genes: ABI1 ADCY4 ALAS1 APP BANP BHLHE40 BLZF1 C1orf109 CBX8 CCDC102B CCDC24 CCNDBP1 CDK18 CDR2 CNTROB CREBZF CYSRT1 DISC1 EFCAB3 FAM161B FSD2 GOLGA2 GOLGA6L9 GPANK1 GPRASP2 GRIPAP1 HOOK2 HSF2BP HTT INSC IQCE KASH5 KDM1A KIAA1328 KLHL42 KRT15 KRT16 KRT27 KRT31 KRT34 KRT36 KRT40 KRTAP10-3 KRTAP10-8 LCN2 LDOC1 LZTS2 MAGED1 MBD3 MDFI MED12L MESD MID2 MKRN3 MTUS2 NOTO NUTM1 PICK1 PIH1D2 PLEKHG4 PNMA1 PNMA5 POLR2J3 POU6F2 PPP1R16A PRDM6 PRKAB2 PRPH PSORS1C2 RAD51D RBCK1 SPAG11B SPAG5 SPAG8 SPDEF SSX2IP TADA2A TEX13A TLE5 TRAF2 TRAPPC6A TRIB3 TRIM10 TRIM32 TRIM54 TRIM73 TRIP6 TSGA10IP UBXN11 USHBP1 XIAP XRN2 ZBED1 ZBTB16 ZBTB42 ZDHHC17 ZFHX3 ZFYVE26 ZIM2	28 interacting genes: ALDH1B1 ATRN COMT CRY2 CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MOCS3 MRPL4 MRPS10 PLEKHF2 PRAME PSMA3 TARDBP TIPARP TOLLIP TTC23 UPF2
Entrez ID		64927	22803
HPRD ID		07777	10309
Ensembl ID		ENSG00000103852	ENSG00000088930
Uniprot IDs		Q5W5X9	B4DZC3 Q9H0D6
PDB IDs
Enriched GO Terms of Interacting Partners?
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