MRPS25 and XPC

Data Source:
BioGRID (affinity chromatography technology)

		MRPS25	XPC
Description		mitochondrial ribosomal protein S25	XPC complex subunit, DNA damage recognition and repair factor
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Ribosome	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 2 Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle XPC Complex Site Of DNA Damage
	Molecular Function	Structural Constituent Of Ribosome	Heteroduplex DNA Loop Binding Bubble DNA Binding Damaged DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity Protein Binding Protein-containing Complex Binding
	Biological Process	Mitochondrial Translational Elongation Mitochondrial Translational Termination	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Assembly Mismatch Repair Response To UV-B Response To Auditory Stimulus Intra-S DNA Damage Checkpoint Response To Drug Positive Regulation Of Transcription, DNA-templated Global Genome Nucleotide-excision Repair UV-damage Excision Repair Regulation Of Mitotic Cell Cycle Phase Transition UV-damage Excision Repair, DNA Incision
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination	SUMOylation of DNA damage response and repair proteins DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Interacting Genes		1 interacting genes: ERCC6	15 interacting genes: CETN2 DDB2 ERCC3 GTF2H1 LSM3 MDM2 PSMD4 RAD23A RAD23B RPA1 SMAD1 TDG USP7 XPA ZNF512B
Entrez ID		64432	7508
HPRD ID		17594	02046
Ensembl ID		ENSG00000131368	ENSG00000154767
Uniprot IDs		P82663	Q01831 X5DRB1
PDB IDs		3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG	2A4J 2GGM 2OBH 2RVB
Enriched GO Terms of Interacting Partners?
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