DCLRE1C and NBN

Data Source:
HPRD (in vitro, in vivo)

		DCLRE1C	NBN
Description		DNA cross-link repair 1C	nibrin
Image
GO Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Nonhomologous End Joining Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Nucleolus Cytosol PML Body Mre11 Complex Site Of Double-strand Break Nuclear Inclusion Body
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity Damaged DNA Binding Endonuclease Activity Protein Binding 5'-3' Exonuclease Activity 5'-3' Exodeoxyribonuclease Activity	Damaged DNA Binding Protein Binding Transcription Factor Binding Protein N-terminus Binding
	Biological Process	Adaptive Immune Response Double-strand Break Repair Via Nonhomologous End Joining Response To Ionizing Radiation B Cell Differentiation Protection From Non-homologous End Joining At Telomere V(D)J Recombination Interstrand Cross-link Repair Nucleic Acid Phosphodiester Bond Hydrolysis	DNA Damage Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Blastocyst Growth DNA Replication Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Arrest Mitotic G2 DNA Damage Checkpoint Cell Population Proliferation Viral Process Regulation Of DNA-dependent DNA Replication Initiation DNA Damage Response, Signal Transduction By P53 Class Mediator Telomeric 3' Overhang Formation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Telomere Maintenance DNA Duplex Unwinding Positive Regulation Of Kinase Activity Signal Transduction In Response To DNA Damage Isotype Switching Neuromuscular Process Controlling Balance Meiotic Cell Cycle T-circle Formation Telomere Maintenance Via Telomere Trimming Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Telomere Capping
Pathways		Nonhomologous End-Joining (NHEJ)	DNA Damage/Telomere Stress Induced Senescence HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination
Drugs
Diseases		T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis	DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494)
Interacting Genes		10 interacting genes: ATM ATR BRCA1 CDKN1B DDB2 MRE11 NBN PRKDC RAD50 TP53BP1	35 interacting genes: ATF2 ATM ATR BAP1 BRCA1 CASC3 CCNE1 CDK9 CHEK2 DCLRE1C EP300 FANCD2 H2AX H3-4 HIF1A MDC1 MRE11 NAT2 NCL PRKDC RAD18 RAD50 RAD51 RECQL5 SIRT1 SNAI1 SUMO2 TERF1 TLK1 TREX1 UBE2D1 UBE2N VRK1 XRCC4 XRCC5
Entrez ID		64421	4683
HPRD ID		05817	04050
Ensembl ID		ENSG00000152457	ENSG00000104320
Uniprot IDs		B3KMX5 Q96SD1	A0A0C4DG07 O60934
PDB IDs		3W1B 3W1G 4HTP 6TT5 6WNL 6WO0 7AF1 7AFS 7AFU 7AGI	5WQD
Enriched GO Terms of Interacting Partners?
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