SIL1 and SETD7

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		SIL1	SETD7
Description		SIL1 nucleotide exchange factor	SET domain containing 7, histone lysine methyltransferase
Image
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Nucleoplasm Chromosome Nucleolus
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Unfolded Protein Binding	P53 Binding Chromatin Binding Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity
	Biological Process	Protein Folding Cotranslational Protein Targeting To Membrane Intracellular Protein Transport Regulation Of Catalytic Activity	Chromatin Organization Cellular Response To DNA Damage Stimulus Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Response To Ethanol Positive Regulation Of Transcription, DNA-templated Regulation Of Histone H3-K9 Methylation Heterochromatin Organization
Pathways			PKMTs methylate histone lysines
Drugs			S-adenosyl-L-homocysteine
Diseases
GWAS		Malaria ( 31844061)	Diastolic blood pressure in combination therapy (beta blocker and thiazide diuretic) ( 29097388) Lean body mass ( 28552196) Salty taste perception in obesity with metabolic syndrome ( 31005965) Serum lycopene concentrations ( 26861389)
Interacting Genes		5 interacting genes: CCND3 HSPA5 SGTB SMAD9 UBQLN1	29 interacting genes: A1BG ATG16L1 DNMT1 E2F1 ESR1 H3-3A H3-4 H3C1 H3C14 H4C1 HCFC1 KLF4 L3MBTL1 MDM2 NR2F2 PPP1R12A PRKAR1A RELA RIOK1 SERTAD1 SIRT1 SMAD7 SOX2 STAT3 STEAP3 TAF10 TAF7 TP53 TRIM21
Entrez ID		64374	80854
HPRD ID		12150	16226
Ensembl ID		ENSG00000120725	ENSG00000145391
Uniprot IDs		A0A0S2Z6B4 Q9H173	B5MCZ8 D6RJA0 Q8WTS6
PDB IDs		6LBN 6LEY	1H3I 1MT6 1MUF 1N6A 1N6C 1O9S 1XQH 2F69 3CBM 3CBO 3CBP 3M53 3M54 3M55 3M56 3M57 3M58 3M59 3M5A 3OS5 3VUZ 3VV0 4E47 4J7F 4J7I 4J83 4J8O 4JDS 4JLG 5AYF 5EG2 5YLT
Enriched GO Terms of Interacting Partners?
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