SEC13 and SEC16B

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SEC13	SEC16B
Description		SEC13 homolog, nuclear pore and COPII coat complex component	SEC16 homolog B, endoplasmic reticulum export factor
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Kinetochore Nuclear Envelope Nucleoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane COPII Vesicle Coat Nuclear Pore Outer Ring Intracellular Membrane-bounded Organelle Host Cell GATOR2 Complex Extracellular Exosome	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Intracellular Membrane-bounded Organelle Endoplasmic Reticulum Exit Site
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Glycolytic Process MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Intracellular Protein Transport Viral Process Viral Transcription Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of TOR Signaling Protein Exit From Endoplasmic Reticulum COPII Vesicle Coating Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus COPII-coated Vesicle Cargo Loading COPII-coated Vesicle Budding Regulation Of Cellular Response To Heat Positive Regulation Of TORC1 Signaling	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Autophagy Endoplasmic Reticulum Organization Golgi Organization Peroxisome Organization Positive Regulation Of Gene Expression Protein Transport Peroxisome Fission COPII Vesicle Coating Positive Regulation Of Protein Exit From Endoplasmic Reticulum Protein Localization To Endoplasmic Reticulum Exit Site
Pathways		ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly COPII-mediated vesicle transport MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation Amino acids regulate mTORC1 EML4 and NUDC in mitotic spindle formation Antigen Presentation: Folding, assembly and peptide loading of class I MHC	COPII-mediated vesicle transport
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)	Adolescent idiopathic scoliosis ( 31417091) Adult body size ( 32376654) Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Bitter non-alcoholic beverage consumption ( 31046077) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 28552196 31513605 29381148 23563607 26426971 19079260 26961502 23669352 24861553 31453325 28892062 25673413 20935630 29273807 23583978 28448500) Body mass index (adult) ( 28430825) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005 26604143) Coffee consumption ( 31046077) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Epigenetic age acceleration in alcohol use disorder ( 31466081) Hand grip strength ( 29691431) Hip circumference ( 28552196 25673412) HOMA-B (corrected for HOMA-IR) ( 30369944) Major depressive disorder ( 27479909) Meat-related diet ( 32066663) Menarche (age at onset) ( 27182965 21102462 25231870) Metabolic syndrome ( 31589552) Night sleep phenotypes ( 27126917) Obese vs. thin ( 30677029) Obesity ( 23563607) Obesity (extreme) ( 30677029) Schizophrenia ( 30285260 23894747) Type 2 diabetes ( 30297969 32499647) Waist circumference ( 28552196 31453325 25673412) Waist circumference variance ( 31453325) Weight ( 28552196 19079260)
Interacting Genes		13 interacting genes: ADGRF5 CFAP43 CLDN12 EGFR HAPLN2 HSPB1 LTB4R2 NUP98 RAB11A SEC16B SEC31A TRAF5 WDR44	3 interacting genes: FBXO7 SEC13 SRPK2
Entrez ID		6396	89866
HPRD ID		02538	11491
Ensembl ID		ENSG00000157020	ENSG00000120341
Uniprot IDs		A8MWR8 P55735	Q96JE7
PDB IDs		3BG0 3BG1 5A9Q
Enriched GO Terms of Interacting Partners?
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