PRDM1 and UTP18

Data Source:
BioGRID (biochemical)

		PRDM1	UTP18
Description		PR/SET domain 1	UTP18 small subunit processome component
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Nucleolus Nuclear Membrane Small-subunit Processome Pwp2p-containing Subcomplex Of 90S Preribosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Histone Deacetylase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Methylation Regulation Of Natural Killer Cell Differentiation Regulation Of Extrathymic T Cell Differentiation Innate Immune Response Cell Fate Commitment Regulation Of NK T Cell Differentiation	RRNA Processing
Pathways		Regulation of TP53 Expression	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463) Diastolic blood pressure ( 30224653) Monobrow ( 27182965) Multiple myeloma ( 27363682) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 23273568 26502338 28714469 19838193 19838195) Systemic sclerosis ( 28314753) Triglyceride levels ( 32203549)	Bipolar disorder ( 31043756) Menarche (age at onset) ( 27182965) Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: ATXN1 H1-1 H3C15 IKZF3 IRF4 KDM1A PIAS1 TLE1 TLE2 TLE5	2 interacting genes: CSNK2A1 ERBB2
Entrez ID		639	51096
HPRD ID		04572	10825
Ensembl ID		ENSG00000057657	ENSG00000011260
Uniprot IDs		A0A3B3IU23 B4DW27 O75626 Q5T4E8	Q9Y5J1
PDB IDs		3DAL
Enriched GO Terms of Interacting Partners?
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