ATXN7 and SYNJ2

Data Source:
BioGRID (genetic interference)

		ATXN7	SYNJ2
Description		ataxin 7	synaptojanin 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Microtubule Cytoskeleton Nuclear Matrix	Cytosol Cytoskeleton Plasma Membrane Cell Projection Membrane Raft Perinuclear Region Of Cytoplasm Presynapse
	Molecular Function	Protein Binding	RNA Binding Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding SH3 Domain Binding PDZ Domain Binding
	Biological Process	Microtubule Cytoskeleton Organization Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Histone Deubiquitination Protein Deubiquitination	Phosphatidylinositol Biosynthetic Process Brain Development Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Membrane Organization
Pathways		HATs acetylate histones Ub-specific processing proteases	Synthesis of PIPs at the plasma membrane Clathrin-mediated endocytosis
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Red cell distribution width ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30054458)	Cannabis use (initiation) ( 22823124) Gamma glutamyl transferase levels ( 29403010) Intraocular pressure ( 29617998) Lipoprotein (a) levels ( 26377243) Platelet distribution width ( 32888494)
Interacting Genes		59 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 USP22 VCP VWF	6 interacting genes: GRB2 ITSN1 ITSN2 NCK1 RAC1 SYNJ2BP
Entrez ID		6314	8871
HPRD ID		06365	10259
Ensembl ID		ENSG00000163635	ENSG00000078269
Uniprot IDs		O15265 Q9UPD8	A0A1W2PR85 B4DG94 O15056
PDB IDs		2KKR	1UFW
Enriched GO Terms of Interacting Partners?
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