ATXN7 and SERINC3

Data Source:
BioGRID (affinity chromatography technology)

		ATXN7	SERINC3
Description		ataxin 7	serine incorporator 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Microtubule Cytoskeleton Nuclear Matrix	Golgi Membrane Plasma Membrane Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Histone Deubiquitination Protein Deubiquitination	L-serine Biosynthetic Process Phosphatidylserine Metabolic Process Sphingolipid Metabolic Process Detection Of Virus Viral Process Innate Immune Response Defense Response To Virus Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		HATs acetylate histones Ub-specific processing proteases	Serine biosynthesis
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Red cell distribution width ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30054458)	Bipolar disorder ( 22925353) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		59 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 USP22 VCP VWF	4 interacting genes: AGTR1 BMP10 DRD2 RPS15
Entrez ID		6314	10955
HPRD ID		06365	06201
Ensembl ID		ENSG00000163635	ENSG00000132824
Uniprot IDs		O15265 Q9UPD8	Q13530
PDB IDs		2KKR
Enriched GO Terms of Interacting Partners?
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