RAB5C and DGKI

Data Source:
BioGRID (affinity chromatography technology)

		RAB5C	DGKI
Description		RAB5C, member RAS oncogene family	diacylglycerol kinase iota
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Early Endosome Lipid Droplet Plasma Membrane Endomembrane System Endocytic Vesicle Early Endosome Membrane Azurophil Granule Membrane Melanosome Extracellular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Axon Synaptic Vesicle Membrane Protein-containing Complex Dendritic Spine Synapse Synaptic Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Endocytosis Regulation Of Endocytosis Neutrophil Degranulation Plasma Membrane To Endosome Transport	Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Lipid Phosphorylation Regulation Of Synaptic Transmission, Glutamatergic
Pathways		Golgi Associated Vesicle Biogenesis Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Effects of PIP2 hydrolysis
Drugs			alpha-Tocopherol succinate
Diseases
GWAS		Coronary artery disease ( 29212778) Fibrinogen levels ( 28107422 26561523) Mean corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737) White blood cell count ( 32888494)	Adult body size ( 32376654) Adventurousness ( 30643258) AIDS progression ( 21502085) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26865924) Brain morphology (MOSTest) ( 32665545) Cognitive decline (age-related) ( 24468470) General risk tolerance (MTAG) ( 30643258) Lean body mass ( 28552196) Schizophrenia ( 28991256 25056061 29483656 30285260) Subcortical volume (MOSTest) ( 32665545) Testosterone levels in polycystic ovary syndrome ( 26284813)
Interacting Genes		15 interacting genes: ALS2CL APP APPL2 EEA1 ERBB2 GLP1R HRAS INCA1 RABAC1 RBSN RIN2 RIN3 SGSM3 TBC1D15 TBC1D17	1 interacting genes: VHL
Entrez ID		5878	9162
HPRD ID		04947	07238
Ensembl ID		ENSG00000108774	ENSG00000157680
Uniprot IDs		A0A024R1U4 P51148	E7EWQ4 E9PFX6 O75912 Q59GE2
PDB IDs		4KYI
Enriched GO Terms of Interacting Partners?
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