PTGIS and ARFGEF2

Data Source:
BioGRID (affinity chromatography technology)

		PTGIS	ARFGEF2
Description		prostaglandin I2 synthase	ADP ribosylation factor guanine nucleotide exchange factor 2
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GO Annotations	Cellular Component	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Caveola Integral Component Of Membrane	Golgi Membrane Golgi Apparatus Trans-Golgi Network Microtubule Organizing Center Cytosol Axonemal Microtubule Membrane Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Dendritic Spine Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Prostaglandin-I Synthase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Hydroperoxy Icosatetraenoate Dehydratase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding GABA Receptor Binding
	Biological Process	Prostaglandin Biosynthetic Process Icosanoid Metabolic Process Cyclooxygenase Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Hypoxia Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis	Receptor Recycling Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Endomembrane System Organization Protein Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Regulation Of Catalytic Activity
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Nicotinamide salvaging Eicosanoids Sterols are 12-hydroxylated by CYP8B1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Association of TriC/CCT with target proteins during biosynthesis
Drugs		Phenylbutazone Epoprostenol (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-1-Octen-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}-5-heptenoic acid
Diseases			Periventricular nodular heterotopia (PVNH)
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Schizophrenia ( 25056061 29483656 30285260)	Adult body size ( 32376654) Anger ( 24489884) Birth weight ( 31043758) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Offspring birth weight ( 31043758) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625)
Interacting Genes		3 interacting genes: APP PTGS1 PTGS2	9 interacting genes: ARFGEF1 EXOC7 GABRB1 GABRB2 GABRB3 PNPLA2 PRKAR1A PRKAR2A PRPF40A
Entrez ID		5740	10564
HPRD ID		09046	09250
Ensembl ID		ENSG00000124212	ENSG00000124198
Uniprot IDs		Q16647	Q59FR3 Q86TH5 Q9Y6D5
PDB IDs		2IAG 3B6H	3L8N 3SWV
Enriched GO Terms of Interacting Partners?
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