PTGFR and NOC2L

Data Source:
BioGRID (two hybrid, x-ray crystallography)
HPRD (in vivo, in vitro, two hybrid)

		PTGFR	NOC2L
Description		prostaglandin F receptor	NOC2 like nucleolar associated transcriptional repressor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Noc1p-Noc2p Complex Noc2p-Noc3p Complex
	Molecular Function	Prostaglandin F Receptor Activity	Chromatin Binding Transcription Corepressor Activity RNA Binding Protein Binding Nucleosome Binding Histone Binding Repressing Transcription Factor Binding
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Parturition Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Response To Estradiol Response To Lipopolysaccharide Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of Apoptotic Process Cellular Response To Prostaglandin D Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of B Cell Apoptotic Process Apoptotic Process Chromatin Assembly Cellular Response To UV Negative Regulation Of Histone Acetylation Ribosomal Large Subunit Biogenesis Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Prostanoid ligand receptors G alpha (q) signalling events	Regulation of TP53 Activity through Phosphorylation
Drugs		Travoprost Latanoprost Bimatoprost Dinoprost tromethamine Tafluprost Latanoprostene bunod
Diseases
GWAS		Bipolar disorder ( 22182935) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Skin fluorescence in type 1 diabetes ( 27207532) Systolic blood pressure (alcohol consumption interaction) ( 24376456)	California verbal learning test score ( 31596458) Pancreatic cancer ( 29422604)
Interacting Genes		5 interacting genes: AGTR1 PTGDS PTGER1 PTGER2 PTGES2	10 interacting genes: APP ATN1 ATXN7 H2AC18 H2BP1 H3-4 H4-16 LRIF1 PPP1CA RBFOX1
Entrez ID		5737	26155
HPRD ID		08988	13166
Ensembl ID		ENSG00000122420	ENSG00000188976
Uniprot IDs		P43088	Q9Y3T9
PDB IDs
Enriched GO Terms of Interacting Partners?
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