PTGFR and CTH

Data Source:
BioGRID (affinity chromatography technology)

		PTGFR	CTH
Description		prostaglandin F receptor	cystathionine gamma-lyase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Prostaglandin F Receptor Activity	Cystathionine Gamma-lyase Activity Protein Binding Calmodulin Binding Carbon-sulfur Lyase Activity Pyridoxal Phosphate Binding Identical Protein Binding L-cystine L-cysteine-lyase (deaminating) L-cysteine Desulfhydrase Activity
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Parturition Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Response To Estradiol Response To Lipopolysaccharide Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of Apoptotic Process Cellular Response To Prostaglandin D Stimulus	Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Cysteine Biosynthetic Process Via Cystathionine Cysteine Biosynthetic Process Transsulfuration Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Sulfhydration Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homotetramerization Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Prostanoid ligand receptors G alpha (q) signalling events	Degradation of cysteine and homocysteine Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se
Drugs		Travoprost Latanoprost Bimatoprost Dinoprost tromethamine Tafluprost Latanoprostene bunod	Pyridoxal phosphate Cysteine 2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic Acid Carboxymethylthio-3-(3-Chlorophenyl)-1,2,4-Oxadiazol L-2-amino-3-butynoic acid
Diseases			Cystathioninuria
GWAS		Bipolar disorder ( 22182935) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Skin fluorescence in type 1 diabetes ( 27207532) Systolic blood pressure (alcohol consumption interaction) ( 24376456)	Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Brain volume in infants (grey matter) ( 28763065) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Seasonality and depression ( 30217971)
Interacting Genes		5 interacting genes: AGTR1 PTGDS PTGER1 PTGER2 PTGES2	4 interacting genes: GUCD1 NTAQ1 RECK SDCBP2
Entrez ID		5737	1491
HPRD ID		08988	09633
Ensembl ID		ENSG00000122420	ENSG00000116761
Uniprot IDs		P43088	P32929
PDB IDs			2NMP 3COG 3ELP 5EIG 5TSU 5TT2 6NBA 6OVG
Enriched GO Terms of Interacting Partners?
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