PAK5 and ARHGEF19

Data Source:
BioGRID (two hybrid)

		PAK5	ARHGEF19
Description		p21 (RAC1) activated kinase 5	Rho guanine nucleotide exchange factor 19
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Synapse	Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	GTPase Activator Activity Protein Binding
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Signal Transduction Learning Memory Locomotory Behavior Cell Population Proliferation Cell Migration Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	G Protein-coupled Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Wound Healing Positive Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Activation Of GTPase Activity
Pathways		Activation of RAC1	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs		Fostamatinib
Diseases
GWAS		Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701)	Apolipoprotein B levels ( 32203549) Facial morphology ( 31763980) Gamma glutamyl transferase levels ( 29403010) Initial pursuit acceleration ( 29064472) LDL cholesterol levels ( 32203549)
Interacting Genes		34 interacting genes: ARHGEF19 ARMC7 ATPAF2 BAD CARD9 CATSPER1 CCDC57 CCNG1 CDC42 CRBN CSNK1D DDX6 DNPEP EMD ENKD1 EXOSC1 FHL3 GCC1 INKA1 LENG1 LNX1 LZTS2 MYO15B NTAQ1 PDLIM7 PRPF31 PSMF1 PTPN21 RAC1 RHOJ SORBS3 TSGA10 TUBGCP4 UXT	2 interacting genes: PAK5 RHOA
Entrez ID		57144	128272
HPRD ID		06423	10659
Ensembl ID		ENSG00000101349	ENSG00000142632
Uniprot IDs		B0AZM9 Q9P286	B4DN02 Q8IW93
PDB IDs		2F57
Enriched GO Terms of Interacting Partners?
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