PCID2 and SEM1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PCID2	SEM1
Description		PCI domain containing 2	SEM1 26S proteasome complex subunit
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GO Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Pore Nuclear Basket Transcription Export Complex 2
	Molecular Function	Double-stranded DNA Binding RNA Binding Protein Binding
	Biological Process	Posttranscriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Transcription Elongation From RNA Polymerase II Promoter Poly(A)+ MRNA Export From Nucleus Negative Regulation Of Apoptotic Process Regulation Of MRNA Stability Positive Regulation Of B Cell Differentiation Positive Regulation Of Transcription, DNA-templated Spleen Development Nuclear Retention Of Pre-mRNA At The Site Of Transcription Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Cysteine-type Endopeptidase Activity
Pathways			Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252)	Heel bone mineral density ( 30598549)
Interacting Genes		4 interacting genes: EID1 IKZF3 LENG8 SEM1	10 interacting genes: BRCA2 MAP1LC3B NUDT21 PCID2 PSMD3 PSMD6 RAD51 RAD52 RPA1 USP14
Entrez ID		55795	7979
HPRD ID		07749	03182
Ensembl ID		ENSG00000126226	ENSG00000127922
Uniprot IDs		A0A024RE04 Q5JVF3	P60896 Q6IBB7
PDB IDs		3T5X	1IYJ 1MIU 1MJE 3T5X 5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFR 5VFT 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN
Enriched GO Terms of Interacting Partners?
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