PRIM1 and SLC11A2

Data Source:
BioGRID (affinity chromatography technology)

		PRIM1	SLC11A2
Description		DNA primase subunit 1	solute carrier family 11 member 2
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GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Membrane	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosomal Membrane Early Endosome Vacuole Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Cytoplasmic Vesicle Brush Border Membrane Late Endosome Membrane Apical Part Of Cell Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Paraferritin Complex Extracellular Vesicle
	Molecular Function	DNA Primase Activity Protein Binding Metal Ion Binding	Copper Ion Transmembrane Transporter Activity Iron Ion Transmembrane Transporter Activity Manganese Ion Transmembrane Transporter Activity Protein Binding Cadmium Ion Transmembrane Transporter Activity Cobalt Ion Transmembrane Transporter Activity Ferrous Iron Transmembrane Transporter Activity Lead Ion Transmembrane Transporter Activity Nickel Cation Transmembrane Transporter Activity Solute:proton Symporter Activity Cadmium Ion Binding Transition Metal Ion Transmembrane Transporter Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication	Response To Hypoxia Heme Biosynthetic Process Cobalt Ion Transport Copper Ion Transport Iron Ion Transport Manganese Ion Transport Cellular Iron Ion Homeostasis Learning Or Memory Response To Iron Ion Lead Ion Transport Iron Import Into Cell Iron Ion Transmembrane Transport Copper Ion Transmembrane Transport Nickel Cation Transmembrane Transport Dendrite Morphogenesis Erythrocyte Development Multicellular Organismal Iron Ion Homeostasis Cadmium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Proton Transmembrane Transport
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand	Metal ion SLC transporters Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) Iron uptake and transport
Drugs			Ferric maltol
Diseases
GWAS		Appendicular lean mass ( 33097823) Asthma ( 31619474) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677) Plateletcrit ( 32888494 27863252) Red blood cell count ( 29403010)
Interacting Genes		4 interacting genes: MDC1 MRPL38 PRIM2 TP53	1 interacting genes: VPS35
Entrez ID		5557	4891
HPRD ID		08899	02750
Ensembl ID		ENSG00000198056	ENSG00000110911
Uniprot IDs		P49642	A0A0X8GKR4 P49281
PDB IDs		4BPU 4BPW 4BPX 4LIK 4LIL 4MHQ 4RR2 5EXR 6R4S 6R4T 6R4U 6R5D 6R5E 6RB4	5F0L 5F0M 5F0P
Enriched GO Terms of Interacting Partners?
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