TRAPPC14 and KMT2E

Data Source:
BioGRID (two hybrid)

		TRAPPC14	KMT2E
Description		trafficking protein particle complex subunit 14	lysine methyltransferase 2E (inactive)
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Midbody Centriolar Satellite Intracellular Membrane-bounded Organelle Mitotic Spindle TRAPPII Protein Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Plasma Membrane Nuclear Body Nuclear Speck Protein-containing Complex Transcriptionally Active Chromatin
	Molecular Function	Protein Binding Alpha-tubulin Binding	Protein Binding Histone-lysine N-methyltransferase Activity Enzyme Binding Methylated Histone Binding Metal Ion Binding
	Biological Process	Regulation Of Cell Population Proliferation Cilium Assembly	Neutrophil Mediated Immunity DNA Methylation Cell Cycle Arrest Erythrocyte Differentiation Histone Lysine Methylation Neutrophil Activation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Histone H3-K4 Trimethylation
Pathways			PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS			Advanced age-related macular degeneration ( 26691988) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) General risk tolerance (MTAG) ( 30643258) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Schizophrenia ( 29483656)
Interacting Genes		8 interacting genes: AGXT CYSRT1 KRTAP6-1 NBPF19 NOTCH2NLA TGM1 TMEM50A VWC2	4 interacting genes: ASH2L ATP13A1 CDK1 LAMTOR5
Entrez ID		55262	55904
HPRD ID		07716	10528
Ensembl ID		ENSG00000146826	ENSG00000005483
Uniprot IDs		B3KNS5 Q8WVR3	Q8IZD2
PDB IDs			2LV9 4L58 5HT6
Enriched GO Terms of Interacting Partners?
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