UACA and AHCYL1

Data Source:
BioGRID (two hybrid)

		UACA	AHCYL1
Description		uveal autoantigen with coiled-coil domains and ankyrin repeats	adenosylhomocysteinase like 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytosol Cytoskeleton Extracellular Exosome	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Apical Plasma Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Extracellular Exosome
	Molecular Function	Molecular_function Protein Binding	RNA Binding Adenosylhomocysteinase Activity Protein Binding Identical Protein Binding
	Biological Process	Biological_process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Apoptotic Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling	MRNA Polyadenylation Protein Export From Nucleus One-carbon Metabolic Process Apoptotic Process Positive Regulation Of Sodium Ion Transport Regulation Of MRNA 3'-end Processing Regulation Of Ion Transmembrane Transporter Activity S-adenosylmethionine Cycle Angiotensin-activated Signaling Pathway Epithelial Fluid Transport Regulation Of Anion Transport Response To Calcium Ion Regulation Of Cardiac Conduction Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways		Regulation of the apoptosome activity	PLC beta mediated events DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Pulmonary function ( 23932459)	Height ( 31562340)
Interacting Genes		13 interacting genes: AHCYL1 ANKRD28 CCDC125 CELSR3 HIF1AN JPH1 KRT31 KRT40 MED14 PRKAR1B RTP2 STAMBP UBQLN2	25 interacting genes: BID CDKN2C DACH1 GEM HBQ1 HEXIM2 HGS HSPA6 ITPR1 JOSD2 LRRK2 MEOX2 MFHAS1 PLEKHG5 PPL PRDM6 PSMD9 RNF6 SLC23A1 SOX30 SRPK1 SRPK2 SUMO2 UACA ZNF165
Entrez ID		55075	10768
HPRD ID		11657	07613
Ensembl ID		ENSG00000137831	ENSG00000168710
Uniprot IDs		Q9BZF9	A0A024R0A8 O43865
PDB IDs			3MTG
Enriched GO Terms of Interacting Partners?
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