DET1 and COP1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		DET1	COP1
Description		DET1 partner of COP1 E3 ubiquitin ligase	COP1 E3 ubiquitin ligase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Golgi Membrane Nucleoplasm Cytosol Nuclear Speck Cul4A-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Ubiquitin Ligase-substrate Adaptor Activity	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Assembly	Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Autodegradation of the E3 ubiquitin ligase COP1 Neddylation
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		2 interacting genes: COP1 DDB1	19 interacting genes: CCT4 CDKN1B DET1 ETS1 ETS2 JUN JUND MLF1 PTPN1 RB1CC1 SFN SIPA1 SOX2 STK40 TP53 TRIB1 UBE2D1 UBE2D2 YWHAZ
Entrez ID		55070	64326
HPRD ID		13140	07455
Ensembl ID		ENSG00000140543	ENSG00000143207
Uniprot IDs		A0A024RC56 Q7L5Y6	Q8NHY2 X5D7N8 X5DNY7
PDB IDs			5HQG 5IGQ
Enriched GO Terms of Interacting Partners?
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