POU2F1 and PPIP5K2

Data Source:
BioGRID (two hybrid)

		POU2F1	PPIP5K2
Description		POU class 2 homeobox 1	diphosphoinositol pentakisphosphate kinase 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Intracellular Membrane-bounded Organelle RNA Polymerase II Transcription Regulator Complex	Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding	Inositol-1,3,4,5,6-pentakisphosphate Kinase Activity Inositol Hexakisphosphate Kinase Activity Inositol Heptakisphosphate Kinase Activity Inositol Hexakisphosphate 5-kinase Activity ATP Binding Diphosphoinositol-pentakisphosphate Kinase Activity Inositol Hexakisphosphate 1-kinase Activity Inositol Hexakisphosphate 3-kinase Activity 5-diphosphoinositol Pentakisphosphate 3-kinase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cytokine-mediated Signaling Pathway SnRNA Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Inositol Metabolic Process Sensory Perception Of Sound Phosphorylation Inositol Phosphate Biosynthetic Process Inositol Phosphate Metabolic Process
Pathways		Interleukin-4 and Interleukin-13 signaling RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter Estrogen-dependent gene expression	Synthesis of pyrophosphates in the cytosol
Drugs
Diseases
GWAS		Asthma ( 31959851 31619474) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Diastolic blood pressure ( 30224653) Liver enzyme levels ( 18940312) Pre-treatment viral load in HIV-1 infection ( 31219150)	Insulinogenic index ( 23263489) Intelligence (MTAG) ( 29326435) Primary biliary cholangitis ( 26394269) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Type 2 diabetes ( 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		68 interacting genes: APP AR ARPC3 ARRB1 BARD1 BRCA1 CEBPE CREB1 CREM ESR1 FDXR HCFC1 HIVEP1 HMGA1 HMGB2 HNF1A HOXB13 HOXC9 IRF9 LIFR MLLT10 MNAT1 MSX1 NCOR2 NFYA NPAT NR3C1 PARP1 PBX1 PGR PKNOX1 PLK3 POGZ POU2AF1 POU6F2 PPIP5K2 PRKACA PRKDC PRR20A PRR20B PRR20C PRR20D PRR20E RARA RELA RXRA SNAPC4 SNIP1 SNX24 SOX2 SP1 SP4 STAT5A STAT5B STOX1 TBP THRA TLE4 TLE5 TLX2 TNF TXNRD1 UBE2I VDR XRCC6 ZC3H10 ZFHX3 ZMYM6	3 interacting genes: POU2F1 POU6F2 SMARCC1
Entrez ID		5451	23262
HPRD ID		01250	13802
Ensembl ID		ENSG00000143190	ENSG00000145725
Uniprot IDs		A0A024R8Y2 P14859	A0A087WZV0 B4DGV1 O43314
PDB IDs		1CQT 1E3O 1GT0 1HF0 1O4X 1OCT 1POG 1POU	3T54 3T7A 3T99 3T9A 3T9B 3T9C 3T9D 3T9E 3T9F 4HN2 4NZM 4NZN 4NZO 4Q4C 4Q4D 5BYA 5BYB 5DGH 5DGI 6N5C
Enriched GO Terms of Interacting Partners?
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