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PML and JUN
Data Source:
BioGRID
(proximity labelling technology)
PML
JUN
Description
PML nuclear body scaffold
Jun proto-oncogene, AP-1 transcription factor subunit
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Heterochromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nuclear Matrix
PML Body
Early Endosome Membrane
Extrinsic Component Of Endoplasmic Reticulum Membrane
Nuclear Chromosome
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytosol
Plasma Membrane
Transcription Factor AP-1 Complex
Molecular Function
DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
SUMO Binding
Protein Homodimerization Activity
SMAD Binding
Sumo-dependent Protein Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Activating Transcription Factor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
RNA Binding
GTPase Activator Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
CAMP Response Element Binding
Identical Protein Binding
Ubiquitin-like Protein Ligase Binding
Protein-containing Complex Binding
R-SMAD Binding
HMG Box Domain Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Response To Hypoxia
Regulation Of Protein Phosphorylation
Regulation Of Transcription, DNA-templated
Protein Import Into Nucleus
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Cycle Arrest
Transforming Growth Factor Beta Receptor Signaling Pathway
Common-partner SMAD Protein Phosphorylation
Negative Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Response To UV
Response To Gamma Radiation
Regulation Of Calcium Ion Transport Into Cytosol
Fibroblast Migration
Viral Process
Negative Regulation Of Angiogenesis
Protein Ubiquitination
Myeloid Cell Differentiation
Regulation Of Cell Adhesion
Negative Regulation Of Cell Growth
PML Body Organization
Positive Regulation Of Telomere Maintenance
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Interleukin-1 Beta Production
Circadian Regulation Of Gene Expression
Response To Cytokine
Regulation Of Circadian Rhythm
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Entrainment Of Circadian Clock By Photoperiod
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
Cell Fate Commitment
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Fibroblast Proliferation
Retinoic Acid Receptor Signaling Pathway
Maintenance Of Protein Location In Nucleus
Defense Response To Virus
Interferon-gamma-mediated Signaling Pathway
Branching Involved In Mammary Gland Duct Morphogenesis
Protein-containing Complex Assembly
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Cellular Response To Interleukin-4
Cellular Senescence
Extrinsic Apoptotic Signaling Pathway
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Viral Release From Host Cell
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Double-strand Break Repair
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Release Of Cytochrome C From Mitochondria
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Ras Protein Signal Transduction
Aging
Learning
Circadian Rhythm
Response To Radiation
Response To Mechanical Stimulus
Response To Lipopolysaccharide
Response To Cytokine
Cellular Response To Reactive Oxygen Species
Fc-epsilon Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Response To Drug
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Negative Regulation Of DNA Binding
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Negative Regulation By Host Of Viral Transcription
Positive Regulation By Host Of Viral Transcription
Positive Regulation Of Monocyte Differentiation
Positive Regulation Of DNA Replication
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-binding Transcription Factor Activity
Cellular Response To Potassium Ion Starvation
Response To CAMP
Regulation Of Cell Cycle
Membrane Depolarization
SMAD Protein Signal Transduction
Cellular Response To Cadmium Ion
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Positive Regulation Of DNA-templated Transcription, Initiation
Pathways
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Regulation of TP53 Activity through Acetylation
Interferon gamma signaling
Regulation of RUNX1 Expression and Activity
Regulation of PTEN localization
HCMV Early Events
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated MAPK activation
Activation of the AP-1 family of transcription factors
Activation of anterior HOX genes in hindbrain development during early embryogenesis
MAPK6/MAPK4 signaling
TP53 Regulates Transcription of DNA Repair Genes
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
WNT5:FZD7-mediated leishmania damping
Drugs
Arsenic trioxide
Adapalene
Vinblastine
Pseudoephedrine
Irbesartan
Arsenic trioxide
LGD-1550
Diseases
Acute myeloid leukemia (AML)
GWAS
Accelerometer-based physical activity measurement (fraction of time with accelerations >425 milli-gravities) (
29899525
)
Appendicular lean mass (
33097823
)
Birth weight (
31043758
)
Height (
28552196
20881960
25282103
)
Insomnia symptoms (never/rarely vs. sometimes/usually) (
30804566
)
Insomnia symptoms (never/rarely vs. usually) (
30804566
)
Myopia (pathological) (
23049088
)
Paget's disease (
21623375
)
Physical activity (overall physical activity time) (
30531941
)
White blood cell count (
32888494
)
Cognitive performance (
19734545
)
Night sleep phenotypes (
27126917
)
Interacting Genes
109 interacting genes:
ADH1B
ANKRD2
ARID3A
ARNT
ATF2
ATXN1
AURKA
AXIN1
BANP
BCL2
BCL6
CASP8AP2
CCNT1
CDK1
CDK2
CDK6
CHFR
CREBBP
CSNK2A1
DAXX
EGFR
EIF4E
ELF4
EP300
ERCC6
FOS
GATA1
GATA2
HDAC1
HDAC2
HDAC3
HHEX
HIPK2
HTT
KAT5
KAT6A
KLHL20
MAD1L1
MAPK11
MAPK14
MDM2
MED7
MXD1
MYB
MYC
NACC1
NCOA2
NCOR1
NCOR2
NFKB1
NR3C1
NR4A1
PAWR
PAXIP1
PCBD2
PIAS1
PIAS2
PIN1
PLAGL1
PLSCR1
POLR2E
PPARG
PSMA3
RARA
RB1
RBX1
RELA
RNF111
RNF125
RPL11
RXRA
SENP1
SENP2
SH3GL1
SIAH2
SIN3A
SIRT1
SKI
SMAD3
SP1
SP100
SRF
STAT3
SUMO1
SUMO2
SUMO3
SUV39H1
SYNE2
TDG
TERF2IP
TGFBR1
TGFBR2
TGIF1
THRA
TOPBP1
TP53
TP63
TP73
TRIB3
TRIM24
TRIM27
TRIM69
UBE2I
UBE2U
UBE3A
USP11
ZBTB16
ZFYVE9
ZNF451
180 interacting genes:
ABL1
AKAP5
APLP2
APP
AR
ARRB1
ATF1
ATF2
ATF3
ATF4
BATF
BATF2
BBS7
BCL3
BCL6
BLM
BRCA1
CASP9
CCND1
CEBPE
CEBPG
CLINT1
COP1
COPS5
CREB3
CREB5
CREBBP
CSNK2A1
DACH1
DDIT3
DDX21
DHX9
DNMT3L
EDF1
EGR1
ELF3
ELOF1
EN1
EP300
EPAS1
ERG
ESR1
ETS1
ETS2
ETV1
ETV4
EWSR1
FBXW7
FOS
FOSB
FOSL1
FOSL2
GATA2
GOPC
GSK3B
GTF2B
GTF2E2
GTF2F1
GTF2F2
HCFC1
HDAC3
HDAC9
HDGF
HHEX
HIF1A
HMGA1
HNRNPM
HOXA9
HOXC8
HSP90AA1
HSPA8
IKBKB
IRAK1
ITCH
ITPK1
JDP2
KLF5
KMT2C
KPNA2
M6PR
MACF1
MAF
MAFB
MAP2K4
MAP2K7
MAPK1
MAPK10
MAPK11
MAPK14
MAPK3
MAPK8
MAPK9
MAPKAPK5
MAPRE3
MBD3
MDM2
MOK
MTA1
MYBBP1A
MYOD1
NACA
NAT14
NCOA1
NCOA2
NCOA3
NCOA6
NCOR2
NEDD4
NELFB
NFE2L1
NFE2L2
NFYA
NR3C1
NR5A1
NRIP1
NTRK3
PACS1
PHOX2A
PIAS1
PIAS2
PIN1
POU1F1
PPARG
PPP3CB
PPP4C
PRKD1
PRKDC
PRRC2A
RB1
RBM39
RELA
RNF187
RPL18A
RPS6KA2
RUNX1
RUNX2
SKI
SMAD2
SMAD3
SMAD4
SMARCD1
SMARCD3
SNAPC5
SNRK
SOX10
SOX8
SP1
SPI1
SPIB
STAT1
STAT3
STAT4
STRN4
SUMO1
SUMO2
SUMO3
SUMO4
TAF1
TAF4
TBP
TCF20
TCF4
TDG
TGIF1
TOP1
TOP2A
TP53
TPM1
TPM2
TRAF2
TRIP4
TSC22D3
TSG101
UBB
UBC
UBE2I
USP6
VAV1
VDR
ZBTB7C
Entrez ID
5371
3725
HPRD ID
00023
01302
Ensembl ID
ENSG00000140464
ENSG00000177606
Uniprot IDs
P29590
P05412
PDB IDs
1BOR
2MVW
2MWX
4WJN
4WJO
5YUF
6IMQ
6UYO
6UYP
6UYQ
6UYR
6UYS
6UYT
6UYU
6UYV
1A02
1FOS
1JNM
1JUN
1S9K
1T2K
5FV8
5T01
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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