BCO1 and DHX38

Data Source:
HPRD (in vitro, in vivo)

		BCO1	DHX38
Description		beta-carotene oxygenase 1	DEAH-box helicase 38
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Intracellular Anatomical Structure Nucleus Nucleoplasm Spliceosomal Complex Membrane Catalytic Step 2 Spliceosome
	Molecular Function	Beta-carotene 15,15'-monooxygenase Activity Carotenoid Dioxygenase Activity Metal Ion Binding	RNA Binding RNA Helicase Activity Protein Binding ATP Binding
	Biological Process	Retinoid Metabolic Process Carotene Catabolic Process Vitamin A Biosynthetic Process Retinol Metabolic Process Retinal Metabolic Process Beta-carotene Metabolic Process	MRNA Splicing, Via Spliceosome RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing
Pathways		Retinoid metabolism and transport	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS			anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Blood protein levels ( 28240269 23696881) Cholesterol, total ( 25961943 20686565) Coronary artery disease ( 29212778) Depression ( 29700475) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) LDL cholesterol ( 25961943 20686565) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 22916037) Red blood cell count ( 32888494) Serum metabolite levels (CMS) ( 31636271) Urate levels ( 31578528)
Interacting Genes			8 interacting genes: CDC40 CSNK2A1 MFAP1 PPP4C SNRNP200 TERF2IP U2AF1 WBP4
Entrez ID		53630	9785
HPRD ID		12042	05720
Ensembl ID		ENSG00000135697	ENSG00000140829
Uniprot IDs		Q9HAY6	Q92620
PDB IDs			5YZG 6ZYM 7A5P
Enriched GO Terms of Interacting Partners?
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