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UBASH3A and REL
Data Source:
BioGRID
(two hybrid)
UBASH3A
REL
Description
ubiquitin associated and SH3 domain containing A
REL proto-oncogene, NF-kB subunit
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Extracellular Exosome
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytosol
Molecular Function
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Biological Process
Regulation Of Cytokine Production
Negative Regulation Of T Cell Receptor Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Gene Expression
Negative Regulation Of Interferon-beta Production
Cellular Response To Stress
Response To Cytokine
NIK/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Neuron Death
Pathways
Activation of NF-kappaB in B cells
Drugs
Diseases
Hodgkin lymphoma
GWAS
Asthma (
32296059
)
Autoimmune traits (pleiotropy) (
30572963
)
Celiac disease (
22057235
30572963
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Diverticular disease (
30177863
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Lymphocyte counts (
32888494
)
Medication use (thyroid preparations) (
31015401
)
Monocyte count (
32888494
)
Primary sclerosing cholangitis (
27992413
)
Rheumatoid arthritis (
30423114
24390342
20453842
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Type 1 diabetes (
21829393
25751624
19430480
30572963
18840781
)
Vitiligo (
20410501
27723757
)
Celiac disease (
20190752
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Crohn's disease (
22412388
21102463
)
Erectile dysfunction (
30583798
)
Hodgkin's lymphoma (
21037568
24920014
)
Inflammatory bowel disease (
23128233
)
Psoriasis (
25903422
20953190
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Psoriatic arthritis (
26626624
22170493
)
Rheumatoid arthritis (
30423114
23143596
24390342
20453842
19503088
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Ulcerative colitis (
20228799
)
Interacting Genes
89 interacting genes:
ARRDC1
ARRDC3
BCAR3
C9orf24
CBLB
CBS
CCDC33
CD3E
COPS9
DAZAP2
DDIT4L
DISC1
DLGAP4
DNM2
DTX3
FADS6
FAM83A
FGFR1OP2
GFAP
GOLGA6L9
HSP90AA1
HSP90B1
HSPD1
IKBKG
ISY1-RAB43
KCNE1
KCTD1
KIAA0408
KPRP
KRT14
KRT31
KRT32
KRT35
KRT39
KRT40
LCN2
LNX1
LZTS1
LZTS2
MAP3K7
MKRN1
N4BP3
NSMF
PLEKHB2
PMEPA1
PNMA5
PRDM6
PRKN
PSMC1
PSMC4
REL
RNF216
RNF41
SF3B4
SH3RF1
SHISA6
SLA2
SNRNP48
SOS1
SPRY1
SPRY2
STX11
TAX1BP1
TEKT1
TEKT4
TIMM44
TMCO2
TMEM239
TP53BP2
TP63
TRIM27
TRIM37
TRIM5
TRIM50
TRIM8
TUBB8
UBB
UBC
UBE2L3
VCP
VPS37B
WAS
WASL
WBP11
ZBTB42
ZC2HC1C
ZNF219
ZNF474
ZRANB1
319 interacting genes:
A1CF
AAAS
ACBD4
ACOT12
ACOT8
ACTN3
ADRB2
ADSL
AGPAT4
AKT2
ALOX5
AQP1
AR
ARFIP2
ARIH2
ARL16
ARMC7
ARNT2
ASAP3
ASMTL
ATG9A
ATP6V0D2
ATP6V1C2
ATPAF2
ATXN1
BANP
BARHL2
BBS4
BCL2L15
BCL6
BID
BMF
C11orf68
C12orf75
C14orf119
C1orf109
C1orf50
C1orf56
C1orf74
C9orf72
CABP5
CACNA1S
CALM1
CCNC
CCNE1
CCNJL
CDK18
CDKN1A
CDKN2C
CDKN2D
CDR2L
CENPX
CEP19
CFAP206
CGGBP1
CHAF1A
CHCHD2
CHIC2
CIB3
CINP
CKS1B
CLIC4
CLIP1
COL20A1
COL8A1
CPNE2
CPNE7
CPSF1
CSNK2A1
CTNNA3
CTNNBIP1
CXCL14
CYB5R2
DAAM2
DDX6
DEF6
DGCR6
DHPS
DMRT3
DNTT
DPF2
DYNC1LI1
EFHC1
EHHADH
EIF3A
EIF3D
EIF4A3
EIF4E2
EIF4EBP1
EIF5A
EIF5A2
ELF1
EMD
EML2
EP300
EPHB6
EPM2AIP1
ESRRA
ESRRG
EXOSC1
EXOSC5
EXOSC8
FAAP20
FAM90A1
FHIT
FHL2
FKBP1B
FLAD1
FLNA
FNDC11
FNDC3B
FOXO4
FUT11
GADD45G
GLYCTK
GPKOW
GRAP
GRB2
GTF2B
HAT1
HDAC7
HIP1
HLA-DOA
HNRNPF
HNRNPLL
HSD17B14
HSPA4
HSPA8
HSPB7
IL36RN
KCTD6
KCTD7
KIAA0100
KLHL32
KLHL40
KLHL42
KRTAP9-4
L3MBTL2
LASP1
LENG1
LGALS14
LMO1
LMO2
LNPEP
LSM2
MAD2L2
MAGOHB
MAP3K7CL
MAP3K8
MAPK8
MAPRE3
MB21D2
MBD3
MEMO1
MID2
MIEN1
MIPOL1
MLIP
MMP2
MORF4L1
MORF4L2
MRPL10
MSRB3
MTPN
MTURN
MVP
MYO15B
NABP1
NAGK
NCK2
NDE1
NDUFAF3
NECAP1
NEDD9
NEIL2
NEUROG3
NFKB1
NFKB2
NFKBIA
NFKBIB
NFKBIE
NGB
NKRF
NME7
NMRK1
NOL9
NOTCH1
NOXA1
NR2C2AP
NUCB1
NUDT10
NUDT14
NXT2
OAZ3
OSGIN1
OSTF1
OTUB2
OTUD4
PADI3
PAK1IP1
PARVG
PATE1
PCYT2
PELI2
PGAP6
PICK1
PIH1D2
PLCB4
PLEKHN1
PM20D2
POLE2
POLR1A
POLR2L
POP5
PPP4C
PRDM10
PRKAA2
PRKAB2
PRKN
PRPF31
PSMA1
PSMA4
PSMB8
PSORS1C2
PTGER3
PTK6
QARS1
R3HDM2
RAB29
RAB41
RABIF
RAD23A
RAD51D
RASSF5
RBM39
RECK
RELA
REXO1L6P
RIPPLY1
RNF213
RNF6
RSPH14
RTL8C
RUNX1T1
S100A1
SAMD11
SAT1
SCNM1
SDCBP
SEC14L4
SEC31A
SEPTIN7
SHC3
SIN3A
SIX1
SLC39A13
SLC41A3
SLC6A12
SMG9
SNRNP25
SP1
SPATC1L
SPG21
SPRY1
SRF
STAMBPL1
STK16
SULT2B1
SUOX
SZT2
TBC1D21
TBC1D22B
TBP
TCL1A
TCP11L1
TDO2
THOC1
TLE5
TLX3
TMEM165
TMEM268
TNIP2
TNS2
TRAPPC2L
TRAPPC6A
TRIM27
TRIM68
TRIM74
TSC22D3
TSEN15
TSPOAP1
TSSC4
TSSK3
TSTD2
TTC19
TTC21A
TXNL4B
UBASH3A
UBASH3B
UBE2D4
UBE2K
UBE2Z
UBXN7
VPS25
WNK3
YARS1
YJU2
ZBED8
ZBTB16
ZDHHC24
ZIC1
ZNF417
ZNF446
ZNF550
ZNF564
ZNF572
ZNF688
ZNF76
ZNF765
Entrez ID
53347
5966
HPRD ID
06904
01286
Ensembl ID
ENSG00000160185
ENSG00000162924
Uniprot IDs
P57075
Q04864
PDB IDs
2CRN
5WDI
Enriched GO Terms of Interacting Partners
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