PFDN2 and RGS4

Data Source:
BioGRID (affinity chromatography technology)

		PFDN2	RGS4
Description		prefoldin subunit 2	regulator of G protein signaling 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Prefoldin Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding
	Biological Process	Protein Folding Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Amyloid Fibril Formation	Inactivation Of MAPK Activity Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Heart Rate Response To Cocaine Response To Morphine Positive Regulation Of GTPase Activity Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Actin Filament Organization Negative Regulation Of Glycine Import Across Plasma Membrane Negative Regulation Of Potassium Ion Transmembrane Transport Dorsal Root Ganglion Development Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
Drugs
Diseases
GWAS			Response to fenofibrate (triglyceride levels) ( 27002377) Response to mTOR inhibitor (rapamycin) ( 24009623)
Interacting Genes		9 interacting genes: DBI ERBB3 MAP3K3 PFDN1 PFDN4 PFDN5 SNCA VBP1 ZNF726	13 interacting genes: CALM1 COPB1 COPB2 EGFR ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KRIT1 PLCB1 PTAFR
Entrez ID		5202	5999
HPRD ID		09658	03947
Ensembl ID		ENSG00000143256	ENSG00000117152
Uniprot IDs		B1AQP2 Q9UHV9	A0A024R909 P49798
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD
Enriched GO Terms of Interacting Partners?
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