CDK12 and PCDHB14

Data Source:
HPRD (in vitro)

		CDK12	PCDHB14
Description		cyclin dependent kinase 12	protocadherin beta 14
Image			No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin K-CDK12 Complex Nucleus Nucleoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Speck Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex	Integral Component Of Plasma Membrane Integral Component Of Membrane Synapse
	Molecular Function	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein Kinase Binding Cyclin Binding	Calcium Ion Binding Protein Binding
	Biological Process	Transcription Elongation From RNA Polymerase II Promoter MRNA Processing Protein Phosphorylation RNA Splicing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of MAP Kinase Activity Regulation Of RNA Splicing Protein Autophosphorylation Regulation Of Cell Cycle Phosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of Stem Cell Differentiation	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Chemical Synaptic Transmission Synapse Assembly Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Pathways		TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases
GWAS		Asthma ( 31619474) Blood urea nitrogen levels ( 31152163) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Lung function (FVC) ( 30061609) Menopause (age at onset) ( 26414677) Refractive error ( 32231278) Triglyceride levels ( 30108155)
Interacting Genes		9 interacting genes: CLK1 EWSR1 MBP PIN1 POLR2A PRPF40A SRPK2 SRSF1 SRSF2	16 interacting genes: AKAP8L GOLGA6L9 HNRNPK HNRNPR KHDRBS3 KRT27 KRTAP6-3 MTUS2 PSTPIP1 PURB RBMX RBMY1A1 RBMY1F RBMY1J SRSF3 TRA2B
Entrez ID		51755	56122
HPRD ID		10849	06958
Ensembl ID		ENSG00000167258	ENSG00000120327
Uniprot IDs		Q9NYV4	Q9Y5E9
PDB IDs		4CXA 4NST 4UN0 5ACB 6B3E 6CKX 6TD3
Enriched GO Terms of Interacting Partners?
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