NELFCD and HDAC11

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NELFCD	HDAC11
Description		negative elongation factor complex member C/D	histone deacetylase 11
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Membrane NELF Complex	Histone Deacetylase Complex Nucleus Plasma Membrane
	Molecular Function	RNA Binding Protein Binding	Histone Deacetylase Activity Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription	Chromatin Organization Oligodendrocyte Development Histone Deacetylation Histone H3 Deacetylation
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway
Drugs			Belinostat Panobinostat
Diseases
GWAS		Mean platelet volume ( 32888494 27863252) Platelet distribution width ( 27863252)	Body mass index ( 26426971) Height ( 20881960) Hip circumference adjusted for BMI ( 25673412) Ulcerative colitis ( 26278503)
Interacting Genes		21 interacting genes: AAMP AR ARAF ARPC4 CACNA1A CDSN DNAJA1 ENDOV EPRS1 FRMD5 GSTM4 HDAC11 MTA1 NELFA NELFB PRMT5 SERF2 SMAD4 TXK UBE3A ZNF638	7 interacting genes: CDC25A CDKN1A HDAC6 MAPK6 NELFCD NRM PHYHIP
Entrez ID		51497	79885
HPRD ID		16096	09146
Ensembl ID		ENSG00000101158	ENSG00000163517
Uniprot IDs		H0UI80 Q8IXH7	B5MCQ6 E7ETT9 Q6IA14 Q96DB2
PDB IDs		5L3X 6GML
Enriched GO Terms of Interacting Partners?
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