SERPINB2 and DCC

Data Source:
BioGRID (affinity chromatography technology)

		SERPINB2	DCC
Description		serpin family B member 2	DCC netrin 1 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane	Cytosol Plasma Membrane Axon Schaffer Collateral - CA1 Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Transmembrane Signaling Receptor Activity Netrin Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity Interleukin-12-mediated Signaling Pathway Wound Healing Fibrinolysis Negative Regulation Of Apoptotic Process	Neuron Migration Apoptotic Process Axonogenesis Axon Guidance Negative Regulation Of Neuron Projection Development Spinal Cord Ventral Commissure Morphogenesis Dorsal/ventral Axon Guidance Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Negative Regulation Of Collateral Sprouting Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Neuron Death Negative Regulation Of Netrin-activated Signaling Pathway Negative Regulation Of Dendrite Development
Pathways		Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Caspase activation via Dependence Receptors in the absence of ligand Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs		Urokinase Tenecteplase Lanoteplase
Diseases			Colorectal cancer Gastric cancer Cancer of the anal canal
GWAS		Asthma ( 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Hen's egg allergy ( 29051540) Hip circumference adjusted for BMI ( 28552196) Systolic blood pressure ( 29208002)	Age at first sexual intercourse ( 27089180) Alcoholism (alcohol use disorder factor score) ( 21529783) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Benign prostatic hyperplasia ( 30988330) Body mass index ( 28892062) Body mass index (ever vs never smoking interaction) ( 23192594) Bortezomib-induced peripheral neuropathy in multiple myeloma ( 28317148) Brain morphology (MOSTest) ( 32665545) Chronic back pain ( 30261039) Coenzyme Q10 levels ( 27149984) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 27089181 29700475) Experiencing mood swings ( 29500382) Feeling fed-up ( 29500382) Feeling miserable ( 29500382) Gallbladder cancer ( 22318345) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Glucose homeostasis traits ( 25524916) Gut microbiota relative abundance (unclassified genus belonging to family Clostridiaceae) ( 33208821) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 30591961) Lung function (FVC) ( 30061609 30804560) Mood instability ( 31168069 29187730) Mosquito bite size ( 28199695) Multisite chronic pain ( 31194737) Neurociticism ( 29500382) Nickel levels ( 26025379) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Putamen volume ( 29147026) Response to exercise (triglyceride level interaction) ( 26491034) Response to fenofibrate (total cholesterol levels) ( 27002377) Response to mTOR inhibitor (everolimus) ( 24009623) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 30285260) Short-term memory (digit-span task) ( 30741946) Smoking behaviour (cigarettes smoked per day) ( 27393504) Smoking status (ever vs never smokers) ( 30643258) Subcortical brain region volumes ( 25607358) Survival in colorectal cancer (distant metastatic) ( 26586795)
Interacting Genes		7 interacting genes: APP CDC42 IRF3 PLAU PRPF8 PSMB1 RB1	28 interacting genes: ADORA2B ALDOB ANP32B APPL1 AR BARD1 CASP3 CASP9 CORO2A CTSV FBP1 HEMGN MAPK3 MAZ NCK1 NTN1 PITPNA PTK2 RASA1 RPL5 SFRP2 SIAH1 SIAH2 TBC1D2 TDRD7 TMOD1 TRMO TSTD2
Entrez ID		5055	1630
HPRD ID		01420	00391
Ensembl ID		ENSG00000197632	ENSG00000187323
Uniprot IDs		P05120	P43146 Q49AK4
PDB IDs		1BY7 1JRR 2ARQ 2ARR	2ED7 2ED8 2ED9 2EDB 2EDD 2EDE 3AU4 4URT 5X83
Enriched GO Terms of Interacting Partners?
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