DELEC1 and TNFSF15

Data Source:
HPRD (in vivo)

		DELEC1	TNFSF15
Description		deleted in esophageal cancer 1	TNF superfamily member 15
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function		Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Immune Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Tumor Necrosis Factor-mediated Signaling Pathway
Pathways			TNFs bind their physiological receptors
Drugs
Diseases			Crohn's disease
GWAS			Asthma ( 32296059) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 30500874 21102463 32581322 26891255 23266558) Inflammatory bowel disease ( 27569725 18758464 23128233) Leprosy ( 20018961 25642632) Metabolite levels ( 23823483) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 28425483 23000144 28062665 30643196) Ulcerative colitis ( 20848476 21297633) Ulcerative colitis or Crohn's disease ( 21699788)
Interacting Genes		29 interacting genes: ARNTL BHLHE41 CIPC CLOCK CRY1 CRY2 CSNK1E CSNK2A1 CSNK2A2 CSNK2B EZH2 FBXL15 GSK3B NFIL3 NONO NPAS2 NR1D2 PER1 PER2 PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1A PPP2R1B PPP2R5D PPP2R5E RORB RORC	2 interacting genes: TNFRSF25 TNFRSF6B
Entrez ID		50514	9966
HPRD ID		16068	04956
Ensembl ID		ENSG00000173077	ENSG00000181634
Uniprot IDs			A0A0U5JA19 O95150
PDB IDs			2O0O 2QE3 2RE9 2RJK 2RJL 3K51 3MI8
Enriched GO Terms of Interacting Partners?
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