SYCP3 and NR2F2

Data Source:
BioGRID (proximity labelling technology)

		SYCP3	NR2F2
Description		synaptonemal complex protein 3	nuclear receptor subfamily 2 group F member 2
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Synaptonemal Complex Lateral Element Nucleus	Nucleus Nucleoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Retinoic Acid Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding
	Biological Process	Male Meiosis I Spermatid Development Spermatogenesis, Exchange Of Chromosomal Proteins Cell Division Meiotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Maternal Placenta Development Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Systemic Arterial Blood Pressure Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Fertilization Anterior/posterior Pattern Specification Radial Pattern Formation Negative Regulation Of Endothelial Cell Migration Cell Differentiation Intracellular Receptor Signaling Pathway Forebrain Development Response To Estradiol Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Anatomical Structure Development Limb Development Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Lymphatic Endothelial Cell Fate Commitment
Pathways		Meiotic synapsis	Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases		Azoospermia, including: Azoospermia; Azoospermia due to perturbations of meiosis
GWAS		Brain morphology (MOSTest) ( 32665545)	Adventurousness ( 30643258) Birth weight ( 31043758) Cannabis use ( 27023175) Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphangioleiomyomatosis (sporadic) ( 31000673) Metabolite levels ( 23823483) Motion sickness ( 25628336) Optic disc area ( 25631615) Optic disc size ( 31809533) Photic sneeze reflex ( 27182965) PR interval ( 32439900) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Sex hormone-binding globulin levels ( 22829776) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659)
Interacting Genes		6 interacting genes: C14orf119 CDC37 LIG4 NXF1 PABPC1 SYCP2	18 interacting genes: BCL11A BCL11B BIK EP300 HDAC1 HIPK3 MYOD1 NCOR2 NR2F6 NR3C1 NSD1 PHB2 PIAS1 SETD7 SQSTM1 TENT5A TRIM24 TRIP4
Entrez ID		50511	7026
HPRD ID		07265	00139
Ensembl ID		ENSG00000139351	ENSG00000185551
Uniprot IDs		A0A024RBF8 Q8IZU3	F1D8R0 P24468
PDB IDs		4CPC	3CJW
Enriched GO Terms of Interacting Partners?
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