SERPINC1 and ATP1B1

Data Source:
HPRD (in vitro)

		SERPINC1	ATP1B1
Description		serpin family C member 1	ATPase Na+/K+ transporting subunit beta 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Organelle Membrane Sperm Flagellum Sarcolemma Extracellular Exosome Extracellular Vesicle
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Identical Protein Binding	ATPase Activator Activity Protein Binding Protein C-terminus Binding Protein Kinase Binding MHC Class II Protein Complex Binding Protein-macromolecule Adaptor Activity Protein Heterodimerization Activity ATPase Binding
	Biological Process	Acute Inflammatory Response To Antigenic Stimulus Response To Nutrient Lactation Blood Coagulation Negative Regulation Of Endopeptidase Activity Post-translational Protein Modification Cellular Protein Metabolic Process Regulation Of Blood Coagulation, Intrinsic Pathway	Response To Hypoxia Cellular Calcium Ion Homeostasis Cellular Sodium Ion Homeostasis Cell Adhesion Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cellular Potassium Ion Homeostasis Positive Regulation Of ATPase Activity Ion Transmembrane Transport Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Protein Transport Into Plasma Membrane Raft ATP Metabolic Process Protein Stabilization Leukocyte Migration Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Protein Localization To Plasma Membrane Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cation Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Sodium Ion Export Across Plasma Membrane Positive Regulation Of Calcium:sodium Antiporter Activity Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium:potassium-exchanging ATPase Activity Regulation Of Cardiac Conduction Potassium Ion Import Across Plasma Membrane
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Basigin interactions Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs		Ardeparin Fondaparinux Heparin Enoxaparin N-Formylmethionine SR-123781A Sulodexide Danaparoid Dalteparin Tinzaparin Nadroparin Copper Protamine sulfate Bemiparin Antithrombin III human
Diseases		Inherited thrombophilia
GWAS		Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549)	Coronary artery disease ( 29212778 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732 25055868) Fuchs's corneal dystrophy ( 28358029) Mitochondrial DNA levels ( 25240745) QT interval ( 23166209 29213071 24952745 19305409 29874175) Rosacea symptom severity ( 29771307)
Interacting Genes		6 interacting genes: F2 KLK1 KLK2 KLK6 PLG SDC2	21 interacting genes: AGTR1 BACE1 BARD1 BRCA1 CRIP2 DDAH2 EGFR EZH2 FXYD1 FXYD7 GCH1 HTR2B KMT2B LRIF1 NDRG2 PAXIP1 PSME1 TRIM14 TRMT2A TSC22D2 USP4
Entrez ID		462	481
HPRD ID		00122	01663
Ensembl ID		ENSG00000117601	ENSG00000143153
Uniprot IDs		A0A024R944 P01008	A3KLL5 P05026
PDB IDs		1ANT 1ATH 1AZX 1BR8 1DZG 1DZH 1E03 1E04 1E05 1JVQ 1LK6 1NQ9 1OYH 1R1L 1SR5 1T1F 1TB6 2ANT 2B4X 2B5T 2BEH 2GD4 2HIJ 2ZNH 3EVJ 3KCG 4EB1
Enriched GO Terms of Interacting Partners?
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