IYD and SYNE1

Data Source:
BioGRID (two hybrid)

		IYD	SYNE1
Description		iodotyrosine deiodinase	spectrin repeat containing nuclear envelope protein 1
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GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Membrane	P-body Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytoskeleton Integral Component Of Membrane Sarcomere Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Postsynaptic Membrane
	Molecular Function	Iodide Peroxidase Activity Protein Binding FMN Binding Oxidoreductase Activity	RNA Binding Actin Binding Protein Binding Lamin Binding Enzyme Binding Protein Homodimerization Activity Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity
	Biological Process	Tyrosine Metabolic Process Thyroid Hormone Generation Thyroid Hormone Metabolic Process Cellular Oxidant Detoxification	Nucleus Organization Golgi Organization Spermatogenesis Muscle Cell Differentiation Nuclear Matrix Anchoring At Nuclear Membrane
Pathways		Thyroxine biosynthesis	Meiotic synapsis
Drugs		3,5-Diiodotyrosine
Diseases		Thyroid dyshormonogenesis; Dyshormogenetic goiter	Emery-Dreifuss muscular dystrophy Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Anger ( 24489884)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 28115744 21926972 31043756 28072414 20351715 21738484) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Body mass index ( 26426971) Endometriosis ( 28537267) Heel bone mineral density ( 30598549 28869591) Post bronchodilator FEV1 ( 26634245) Tonometry ( 17903302) Uterine fibroids ( 31249589 30194396 31649266)
Interacting Genes		1 interacting genes: TRIM69	21 interacting genes: ACTC1 APC BDKRB2 CAPN1 CDC42 CDC5L CEP63 DISC1 DTNBP1 ECPAS EMD LINC00839 LMNA MTDH MUSK MYOM1 NDEL1 SH3BP5 TNIK TP53RK USP21
Entrez ID		389434	23345
HPRD ID		16668	09762
Ensembl ID		ENSG00000009765	ENSG00000131018
Uniprot IDs		Q2VPV9 Q6PHW0	A0A0C4DG40 B4E3R1 B7Z9Y6 F8WAI0 Q8NF91
PDB IDs		4TTB 4TTC 5YAK	4DXR 6R15
Enriched GO Terms of Interacting Partners?
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