AGRN and MAGED1

Data Source:
BioGRID (two hybrid)

		AGRN	MAGED1
Description		agrin	MAGE family member D1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Golgi Lumen Plasma Membrane Integral Component Of Membrane Lysosomal Lumen Synapse Collagen-containing Extracellular Matrix Extracellular Exosome	Chromatin Nucleus Cytoplasm Plasma Membrane Protein-containing Complex
	Molecular Function	Dystroglycan Binding Structural Constituent Of Cytoskeleton Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Sialic Acid Binding Chondroitin Sulfate Binding Laminin Binding Heparan Sulfate Proteoglycan Binding	Protein Binding Identical Protein Binding
	Biological Process	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Cytoskeleton Organization Signal Transduction G Protein-coupled Acetylcholine Receptor Signaling Pathway Neuromuscular Junction Development Animal Organ Morphogenesis Tissue Development Extracellular Matrix Organization Receptor Clustering Positive Regulation Of GTPase Activity Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Synaptic Growth At Neuromuscular Junction Positive Regulation Of Transcription By RNA Polymerase II Synapse Organization Positive Regulation Of Filopodium Assembly	Regulation Of Transcription, DNA-templated Circadian Regulation Of Gene Expression Regulation Of Apoptotic Process Negative Regulation Of Epithelial Cell Proliferation
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS NCAM1 interactions Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport	NRAGE signals death through JNK Caspase activation via Dependence Receptors in the absence of ligand
Drugs
Diseases		Congenital myasthenic syndrome
GWAS
Interacting Genes		9 interacting genes: ATN1 ATXN7 BOLL CACNA1A DAG1 GFI1B MAGED1 TEPSIN UBC	125 interacting genes: AGRN AKAP9 ARHGEF16 ARID5A ARNT2 BAG3 BAG4 BARD1 BHLHE40 BIRC8 BRCA2 C1orf94 CA8 CAPN7 CCDC120 CCDC33 CDC23 CERCAM CFAP206 CHERP DAB1 DAZAP2 DDX6 DLX4 DLX5 DMRT2 EIF3J EIF4E2 EP300 ERCC3 FAM83A FOXD2 FOXH1 FOXI1 GATA5 GLRA1 GLYCTK GPANK1 GPR135 GRAP2 HEMK1 HGS HIVEP1 HNRNPH1 HNRNPLL HOXC9 HSF2BP KPNA2 KPNA6 KRTAP19-5 KRTAP6-1 KRTAP6-3 LARP4B LENG8 LONRF1 MAPK1IP1L MAPK3 MDFI MEOX2 MGAT5B MKRN3 MPC1 MSX2 NAF1 NGFR NOTCH1 NOTO NPAS4 NUMBL PHF1 PITX1 PJA1 PJA2 PLK1 PNMA5 POM121 PRKAB2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E PRR35 PSMF1 RAMAC RBFOX1 RBFOX2 RBM23 RBPMS RBPMS2 RFX1 RHOXF2 RNF6 RNF8 ROR2 RUSC1 RXFP4 SIM2 SIRT7 SMAP2 SMN1 SMN2 SNRPC SOX10 SOX5 TBX6 TFG TIAL1 TLX3 TRAF4 TRIM28 TSGA10IP TTC23 TTC32 TUBA4A UBQLN2 UNC5A VENTX XIAP YTHDF1 ZFYVE26 ZIC1 ZNF488 ZNF688
Entrez ID		375790	9500
HPRD ID		10550	02202
Ensembl ID		ENSG00000188157	ENSG00000179222
Uniprot IDs		O00468	Q9Y5V3
PDB IDs
Enriched GO Terms of Interacting Partners?
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