IL5 and HSPA9

Data Source:
BioGRID (affinity chromatography technology)

		IL5	HSPA9
Description		interleukin 5	heat shock protein family A (Hsp70) member 9
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	SAM Complex Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Focal Adhesion Mitochondrial Nucleoid Extracellular Exosome MIB Complex
	Molecular Function	Cytokine Activity Interleukin-5 Receptor Binding Protein Binding Growth Factor Activity	RNA Binding Protein Binding ATP Binding ATPase Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding
	Biological Process	MAPK Cascade Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of B Cell Proliferation Positive Regulation Of Eosinophil Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Podosome Assembly	Protein Export From Nucleus Inner Mitochondrial Membrane Organization Iron-sulfur Cluster Assembly Erythrocyte Differentiation Cellular Response To Unfolded Protein Interleukin-12-mediated Signaling Pathway Protein Refolding Negative Regulation Of Apoptotic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Erythrocyte Differentiation Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Hemopoiesis
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling	Mitochondrial protein import Regulation of HSF1-mediated heat shock response Cristae formation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Pranlukast Reslizumab Mepolizumab
Diseases
GWAS		Asthma ( 31959851 31619474) Eosinophil counts ( 29403010 19198610 32888494) Inflammatory bowel disease ( 23128233) Pediatric autoimmune diseases ( 26301688) Rosacea symptom severity ( 29771307)	Autism spectrum disorder or schizophrenia ( 28540026) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Schizophrenia ( 25056061 29483656)
Interacting Genes		1 interacting genes: IL5RA	26 interacting genes: APP DNAJC19 DNLZ ERBB2 ERCC6 FGF1 HSP90B1 HSPBP1 LAMTOR5 LINC01554 LSM8 MATK MVD NELFB PTPN11 PTPRF SIRPA STUB1 SUMO2 SUMO4 SUPT6H TIMM44 TP53 XPO1 YKT6 YWHAG
Entrez ID		3567	3313
HPRD ID		00997	02770
Ensembl ID		ENSG00000113525	ENSG00000113013
Uniprot IDs		P05113	A0A384P5G6 P38646
PDB IDs		1HUL 3QT2 3VA2	3N8E 4KBO 6NHK 6P2U 6PMT
Enriched GO Terms of Interacting Partners?
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