IFNA1 and GLDC

Data Source:
BioGRID (biochemical)

		IFNA1	GLDC
Description		interferon alpha 1	glycine decarboxylase
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Glycine Cleavage Complex
	Molecular Function	Cytokine Activity Type I Interferon Receptor Binding Protein Binding	Glycine Dehydrogenase (decarboxylating) Activity Electron Transfer Activity Glycine Binding Lyase Activity Enzyme Binding Pyridoxal Phosphate Binding Protein Homodimerization Activity Pyridoxal Binding
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Humoral Immune Response Blood Coagulation Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein B Cell Proliferation Response To Exogenous DsRNA Defense Response To Virus Type I Interferon Signaling Pathway	Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System Electron Transport Chain Response To Methylamine Protein-containing Complex Assembly Response To Lipoic Acid
Pathways		Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling TRAF6 mediated IRF7 activation Factors involved in megakaryocyte development and platelet production	Glycine degradation
Drugs			Pyridoxal phosphate
Diseases			Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS			Alanine transaminase levels ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Glycine levels ( 31070104 30837465) Height ( 31562340) Metabolite levels ( 23823483) Metabolite levels (small molecules and protein measures) ( 27005778) Overall survival in osteosarcoma ( 29210060) Periodontal microbiota ( 22699663) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		4 interacting genes: CR2 IFNAR1 IL2 IRF9	1 interacting genes: TLR10
Entrez ID		3439	2731
HPRD ID		00974	01996
Ensembl ID		ENSG00000197919	ENSG00000178445
Uniprot IDs		L0N195 P01562	P23378
PDB IDs		3UX9	6I33 6I34 6I35
Enriched GO Terms of Interacting Partners?
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