ICAM3 and GCC2

Data Source:
BioGRID (biochemical)

		ICAM3	GCC2
Description		intercellular adhesion molecule 3	GRIP and coiled-coil domain containing 2
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome	Nucleoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane
	Molecular Function	Signaling Receptor Binding Integrin Binding Protein Binding	Protein Binding Small GTPase Binding Identical Protein Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Phagocytosis Cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response Cell-cell Adhesion	Protein Targeting To Lysosome Microtubule Organizing Center Organization Protein Localization To Golgi Apparatus Microtubule Anchoring Late Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Regulation Of Protein Exit From Endoplasmic Reticulum Recycling Endosome To Golgi Transport Golgi Ribbon Formation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling	Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)	Excessive hairiness ( 29895819) Eyebrow thickness ( 26926045) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 27863252) Platelet distribution width ( 32888494)
Interacting Genes		20 interacting genes: APP BRICD5 CD209 CLDN19 CLDN4 CLEC4M EDDM3B EZR ITGAD ITGAL ITGB2 MSN NINJ2 PRKCQ SEC22A SFTPC SMCO4 SMIM1 TSPO ZBTB16	3 interacting genes: ARL1 SPOP SRPK2
Entrez ID		3385	9648
HPRD ID		00889	11001
Ensembl ID		ENSG00000076662	ENSG00000135968
Uniprot IDs		A0A024R7C1 K7ERN2 P32942	B3KR21 Q8IWJ2
PDB IDs		1T0P	3BBP
Enriched GO Terms of Interacting Partners?
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