HRH1 and BBS5

Data Source:
BioGRID (biochemical)

		HRH1	BBS5
Description		histamine receptor H1	Bardet-Biedl syndrome 5
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse	Cytosol Axoneme Centriolar Satellite BBSome Ciliary Basal Body Ciliary Membrane
	Molecular Function	G Protein-coupled Receptor Activity Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Neurotransmitter Receptor Activity	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding Phosphatidylinositol-3-phosphate Binding
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Memory Visual Learning Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Regulation Of Vascular Permeability Positive Regulation Of Vasoconstriction Inositol Phosphate-mediated Signaling Regulation Of Synaptic Plasticity Eosinophil Chemotaxis Cellular Response To Histamine G Protein-coupled Serotonin Receptor Signaling Pathway	Heart Looping Visual Perception Protein Transport Melanosome Transport Motile Cilium Assembly Intracellular Transport Response To Stimulus Cilium Assembly
Pathways		Histamine receptors G alpha (q) signalling events	BBSome-mediated cargo-targeting to cilium
Drugs		Citalopram Benzatropine Ziprasidone Clemastine Amitriptyline Olanzapine Cetirizine Terfenadine Buclizine Clozapine Doxylamine Mirtazapine Dexbrompheniramine Loxapine Promazine Triprolidine Prochlorperazine Cyproheptadine Loratadine Imipramine Chlorpromazine Haloperidol Nortriptyline Amoxapine Lamotrigine Hydroxyzine Cinnarizine Astemizole Trazodone Paroxetine Azatadine Trimipramine Risperidone Meclizine Carbinoxamine Epinastine Benzquinamide Olopatadine Propiomazine Tripelennamine Tolazoline Brompheniramine Methdilazine Ketotifen Maprotiline Fexofenadine Desloratadine Azelastine Dimenhydrinate Promethazine Mequitazine Diphenhydramine Emedastine Levocabastine Chlorpheniramine Doxepin Diphenylpyraline Desipramine Orphenadrine Escitalopram Cyclizine Quetiapine Bromodiphenhydramine Aripiprazole Chlorprothixene Alimemazine Paliperidone Methotrimeprazine Aceprometazine Phenindamine Pheniramine Zuclopenthixol Clofedanol Flunarizine Bepotastine Tesmilifene Iloperidone HY10275 OBE101 SO-101 Histamine Epicept NP-1 Cariprazine Mianserin Pizotifen Asenapine Ocaperidone Levocetirizine Esmirtazapine Mepyramine Betahistine Alcaftadine Antazoline Chloropyramine Dimetindene Isothipendyl Perospirone Chlorcyclizine Butriptyline Dosulepin Lorpiprazole Acrivastine Dexchlorpheniramine maleate Thonzylamine Bilastine Rupatadine Aripiprazole lauroxil
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Male-pattern baldness ( 28196072) Mortality in sepsis ( 27639821) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 27618447 27618452)	Iris heterochromicity ( 30895295)
Interacting Genes		11 interacting genes: ADGRA3 ATP6V0A1 CD81 CNBP DHRS7 LIMS2 MAT2B SLC35B1 SLC43A2 WLS YIPF3	2 interacting genes: CRADD KLC3
Entrez ID		3269	129880
HPRD ID		02544	10353
Ensembl ID		ENSG00000196639	ENSG00000163093
Uniprot IDs		P35367	A0A0S2Z626 Q8N3I7
PDB IDs		3RZE	6XTB
Enriched GO Terms of Interacting Partners?
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