HPCA and TNFRSF8

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)

		HPCA	TNFRSF8
Description		hippocalcin	TNF receptor superfamily member 8
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extrinsic Component Of Membrane Axon Dendrite Membrane Neuronal Cell Body Membrane Dendrite Cytoplasm Perikaryon Dendritic Spine Head Glutamatergic Synapse	Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Kinase Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity
	Biological Process	Brain Development Calcium-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity Activation Of Phospholipase D Activity Positive Regulation Of Adenylate Cyclase Activity Inner Ear Development Retina Development In Camera-type Eye Cellular Response To Electrical Stimulus Cellular Response To Calcium Ion Positive Regulation Of Protein Targeting To Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Voltage-gated Calcium Channel Activity Response To Ketamine Response To L-glutamate Cellular Response To Monosodium Glutamate Response To Aroclor 1254	Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus
Pathways			TNFs bind their physiological receptors
Drugs			XmAb 2513 Brentuximab vedotin
Diseases
GWAS			Asthma ( 31959851 32296059) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) Tuberculosis ( 29036319)
Interacting Genes		16 interacting genes: C1QTNF2 CKMT1A CKMT1B CREM DTX2 GATA5 IL36RN MLLT10 MYDGF NAIP NMT1 PRR35 SLC16A3 TEPSIN UQCRB VWC2	7 interacting genes: ALK TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5
Entrez ID		3208	943
HPRD ID		00811	01074
Ensembl ID		ENSG00000121905	ENSG00000120949
Uniprot IDs		P84074	A5D8T4 P28908
PDB IDs		5G4P 5G58 5M6C	1D01
Enriched GO Terms of Interacting Partners?
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