HMGCR and ARHGAP1

Data Source:
HPRD (two hybrid)

		HMGCR	ARHGAP1
Description		3-hydroxy-3-methylglutaryl-CoA reductase	Rho GTPase activating protein 1
Image
GO Annotations	Cellular Component	Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cytoplasm Cytosol Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Sorting Endosome
	Molecular Function	Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Protein Binding Hydroxymethylglutaryl-CoA Reductase Activity NADPH Binding Coenzyme A Binding	GTPase Activator Activity Protein Binding SH3 Domain Binding Small GTPase Binding Cadherin Binding
	Biological Process	Cholesterol Biosynthetic Process Isoprenoid Biosynthetic Process Coenzyme A Metabolic Process Sterol Biosynthetic Process Regulation Of Lipid Metabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Protein Secretion Negative Regulation Of Amyloid-beta Clearance	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Endosomal Transport Transferrin Transport Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Endocytic Recycling
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	Rho GTPase cycle
Drugs		NADH Pravastatin Lovastatin Cerivastatin Simvastatin Atorvastatin Fluvastatin Rosuvastatin Coenzyme A (S)-Hmg-Coa Nicotinamide adenine dinucleotide phosphate Meglutol 1,4-Dithiothreitol TAK-475 Mevastatin Pitavastatin Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Body mass index ( 20935630) Cholesterol ( 31902109) Cholesterol, total ( 24097068 28270201 19060911 25961943 20686565 26582766) Coronary artery disease ( 33020668) LDL cholesterol ( 24097068 18802019 18193044 20864672 19060906 19060911 25961943 20686565 26582766) LDL cholesterol levels ( 32203549 28334899 31087446) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 32154731 29403010) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 21909109 23823483) Metabolite levels (lipoprotein measures) ( 27005778) Quantitative traits ( 19197348) Total cholesterol levels ( 28334899 31087446 30275531) Type 2 diabetes ( 32499647)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Bone mineral density (hip) ( 19801982) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Femoral neck bone mineral density ( 22504420) Neurociticism ( 29500382) Reaction time ( 29844566) Schizophrenia ( 29483656) Suffering from nerves ( 29500382)
Interacting Genes		4 interacting genes: ARHGAP1 INSIG1 PRKACA STARD13	25 interacting genes: ADGRB2 AGTRAP BNIP2 BNIPL CDC42 CHEK2 EPB41L1 HMGCR HSP90AB1 ITPR1 KIF1B LINC01554 MTNR1B PIK3R1 PTPN11 RAC1 RASA1 RHOA RHOC SH3GL1 SMARCD3 SRC TAX1BP1 TUBA4A WAS
Entrez ID		3156	392
HPRD ID		00836	04108
Ensembl ID		ENSG00000113161	ENSG00000175220
Uniprot IDs		A0A024RAP2 P04035	Q07960
PDB IDs		1DQ8 1DQ9 1DQA 1HW8 1HW9 1HWI 1HWJ 1HWK 1HWL 2Q1L 2Q6B 2Q6C 2R4F 3BGL 3CCT 3CCW 3CCZ 3CD0 3CD5 3CD7 3CDA 3CDB	1AM4 1GRN 1OW3 1RGP 1TX4 2NGR 5M6X 5M70 6R3V
Enriched GO Terms of Interacting Partners?
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