HK2 and PTGDS

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		HK2	PTGDS
Description		hexokinase 2	prostaglandin D2 synthase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Centrosome Cytosol Plasma Membrane Membrane Sarcoplasmic Reticulum Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity	Prostaglandin-D Synthase Activity Retinoid Binding Fatty Acid Binding Protein Binding Small Molecule Binding
	Biological Process	Response To Hypoxia Cellular Glucose Homeostasis Response To Ischemia Fructose 6-phosphate Metabolic Process Glycolytic Process Lactation Apoptotic Mitochondrial Changes Negative Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Angiogenesis Regulation Of Glucose Import Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Positive Regulation Of Autophagy Of Mitochondrion In Response To Mitochondrial Depolarization Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Reactive Oxygen Species Metabolic Process	Prostaglandin Biosynthetic Process Cyclooxygenase Pathway Mast Cell Degranulation Regulation Of Circadian Sleep/wake Cycle, Sleep
Pathways		Glycolysis	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Transcriptional regulation of testis differentiation
Drugs			Vitamin A
Diseases
GWAS		Femoral neck bone geometry ( 22087292)	Beta-trace protein levels ( 23328707) Blood protein levels ( 29875488) Corneal structure ( 23291589)
Interacting Genes		9 interacting genes: ENO1 MAGEA12 PRKCE PTGDS SLC2A4 SUMO2 UBQLN1 UBQLN4 ZBTB17	22 interacting genes: ADRB2 AKT1 ARRB2 ATXN1 BCAT2 CACNA1A CAPN1 CARD10 CYSRT1 EGFR HK2 HK3 HSP90AA1 KRTAP10-3 KRTAP10-7 KRTAP12-3 MLH1 PTGER1 PTGER2 PTGFR SHBG UBQLN2
Entrez ID		3099	5730
HPRD ID		03080	08904
Ensembl ID		ENSG00000159399	ENSG00000107317
Uniprot IDs		P52789	A0A024R8G3 P41222
PDB IDs		2NZT 5HEX 5HFU 5HG1	2WWP 3O19 3O22 3O2Y 4IMN 4IMO 4ORR 4ORS 4ORU 4ORW 4ORX 4ORY 4OS0 4OS3 4OS8 5WY9
Enriched GO Terms of Interacting Partners?
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